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Machine translation
1. (WO1998017682) SERINE SUBSTITUTED MUTANTS OF BCL-XL/BCL-2 ASSOCIATED CELL DEATH REGULATOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/017682    International Application No.:    PCT/US1997/019175
Publication Date: 30.04.1998 International Filing Date: 17.10.1997
Chapter 2 Demand Filed:    18.05.1998    
IPC:
A61K 38/00 (2006.01), C07K 14/47 (2006.01)
Applicants: WASHINGTON UNIVERSITY [US/US]; One Brookings Drive, St. Louis, MO 63130 (US) (For All Designated States Except US).
KORSMEYER, Stanley, J. [US/US]; (US) (For US Only)
Inventors: KORSMEYER, Stanley, J.; (US)
Agent: HOLLAND, Donald, R.; Howell & Haferkamp, L.C., Suite 1400, 7733 Forsyth Boulevard, St. Louis, MO 63105 (US)
Priority Data:
08/733,505 18.10.1996 US
Title (EN) SERINE SUBSTITUTED MUTANTS OF BCL-XL/BCL-2 ASSOCIATED CELL DEATH REGULATOR
(FR) MUTANTS A SUBSTITUTION SERINE DE REGULATEUR DE MORT DE CELLULES ASSOCIEES A BCL-XL/BCL-2
Abstract: front page image
(EN)Novel forms of mutant BAD polypeptides or fragments thereof having an amino acid substitution for serine-112 and/or serine-136 are provided along with their encoding polynucleotides. Also disclosed are methods for preparation of the mutant BAD polypeptides and methods for treating disease conditions involving decreased apoptosis.
(FR)La présente invention concerne de nouvelles formes de polypeptides BAD mutants ou des fragments de ceux-ci, comprenant une substitution amino acide au niveau de la sérine-112 et/ou de la sérine-136, et leurs polynucléotides codants. La présente invention concerne, également, des procédés de préparation des polypeptides BAD mutants et des procédés de traitement d'états pathologiques impliquant une apoptose diminuée.
Designated States: AU, CA, JP, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)