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1. WO1998017667 - 6',7'-DIHYDROXYBERGAMOTTIN, A CYTOCHROME P450 IHNIBITOR IN GRAPEFRUIT JUICE

Publication Number WO/1998/017667
Publication Date 30.04.1998
International Application No. PCT/US1997/018599
International Filing Date 16.10.1997
Chapter 2 Demand Filed 13.04.1998
IPC
A61K 31/37 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
366having six-membered rings, e.g. delta-lactones
37Coumarins, e.g. psoralen
A61K 38/13 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
13Cyclosporins
CPC
A61K 31/37
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
366having six-membered rings, e.g. delta-lactones
37Coumarins, e.g. psoralen
A61K 38/13
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides ; , e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
13Cyclosporins
Applicants
  • WAYNE STATE UNIVERSITY [US]/[US]
Inventors
  • EDWARDS, David, J.
  • WOSTER, Patrick, M.
Agents
  • SMITH, DeAnn, F.
Priority Data
60/028,96118.10.1996US
60/054,33224.06.1997US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 6',7'-DIHYDROXYBERGAMOTTIN, A CYTOCHROME P450 IHNIBITOR IN GRAPEFRUIT JUICE
(FR) 6',7'-DIHYDROXYBERGAMOTINE, INHIBITEUR DE CYTOCHROME P450 ANS LE JUS DE PAMPLEMOUSSE
Abstract
(EN)
The present invention provides a composition and methods for inhibiting cytochrome P450 enzyme activity and in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. The present invention provides 6',7'-dihydroxybergamottin, a furanocoumarin, as the compound primarily responsable for the inhibitory effects of grapefruit juice on cytochrome P450 enzyme activity. The present invention also provides a novel synthesis scheme for 6',7'-dihydroxybergamottin.
(FR)
Composition et procédés pour inhiber l'activité des enzymes cytochromes P450 et en particulier pour inhiber l'activité de la sous-famille d'enzymes cytochromes P450 3A, et spécifiquement CYP3A4. L'invention porte sur la 6',7'-dihydroxybergamotine, une furanocoumarine, qui est le composé principalement responsable de l'effet inhibiteur exercé par le jus de pamplemousse sur l'activité du cytochrome P450. L'invention porte également sur une nouvelle méthode de synthèse pour la 6',7'-dihydroxybergamotine.
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Latest bibliographic data on file with the International Bureau