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Machine translation
1. (WO1998017660) PHENYL SPIROETHERCYCLOALKYL TACHYKININ RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/017660    International Application No.:    PCT/US1997/019346
Publication Date: 30.04.1998 International Filing Date: 22.10.1997
Chapter 2 Demand Filed:    18.05.1998    
IPC:
C07D 307/94 (2006.01), C07D 405/10 (2006.01), C07D 405/12 (2006.01), C07D 413/10 (2006.01), C07D 413/12 (2006.01), C07D 417/10 (2006.01), C07D 417/12 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065 (US) (For All Designated States Except US).
CALDWELL, Charles, G. [US/US]; (US) (For US Only).
CHIANG, Yuan-Ching [CN/US]; (US) (For US Only).
DORN, Conrad [US/US]; (US) (For US Only).
FINKE, Paul [US/US]; (US) (For US Only).
HALE, Jeffrey [US/US]; (US) (For US Only).
MacCOSS, Malcolm [GB/US]; (US) (For US Only).
MILLS, Sander [US/US]; (US) (For US Only).
ROBICHAUD, Albert [US/US]; (US) (For US Only)
Inventors: CALDWELL, Charles, G.; (US).
CHIANG, Yuan-Ching; (US).
DORN, Conrad; (US).
FINKE, Paul; (US).
HALE, Jeffrey; (US).
MacCOSS, Malcolm; (US).
MILLS, Sander; (US).
ROBICHAUD, Albert; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065 (US)
Priority Data:
60/029,258 25.10.1996 US
9625843.9 12.12.1996 GB
Title (EN) PHENYL SPIROETHERCYCLOALKYL TACHYKININ RECEPTOR ANTAGONISTS
(FR) ANTAGONISTES DU RECEPTEUR DE PHENYL SPIROETHERCYCLOALKYL TACHYKININE
Abstract: front page image
(EN)The present invention is directed to certain novel compounds represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R?3¿, R?6¿, R?7¿, R?8¿, R?11¿, R?12¿, R?13¿, m, n and the dashed lines are defined herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.
(FR)Cette invention a trait à certains nouveaux composés représentés par la formule structurale (I) ou à leurs sels acceptables du point de vue pharmaceutique. Dans cette formule R?3¿, R?6¿, R?7¿, R?8¿, R?11¿, R?12¿, R?13¿, m, n et les lignes pointillées sont définis dans le descriptif. Elle concerne également des formulations pharmaceutiques contenant ces composés comme ingrédients actifs ainsi que l'utilisation des nouveaux composés et de leurs formulations dans le traitement d'un certain nombre de troubles. Les composés de l'invention, qui sont des antagonistes du récepteur de la tachykinine, se révèlent efficaces dans le traitement de maladies inflammatoires, de douleurs ou de migraines, ainsi que de l'asthme et des vomissements.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, ID, IL, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, SL, TJ, TM, TR, TT, UA, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)