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1. (WO1998017625) NOVEL REMEDIES FOR INFECTIOUS DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/017625    International Application No.:    PCT/JP1997/003812
Publication Date: 30.04.1998 International Filing Date: 22.10.1997
Chapter 2 Demand Filed:    22.10.1997    
IPC:
C07C 237/42 (2006.01), C07D 207/14 (2006.01)
Applicants: DAIICHI PHARMACEUTICAL CO., LTD. [JP/JP]; 14-10, Nihonbashi 3-chome, Chuo-ku, Tokyo 103 (JP) (For All Designated States Except US).
OHTA, Toshiharu [JP/JP]; (JP) (For US Only).
NAKAYAMA, Kiyoshi [JP/JP]; (JP) (For US Only).
OHTSUKA, Masami [JP/JP]; (JP) (For US Only).
INAGAKI, Hiroaki [JP/JP]; (JP) (For US Only).
NISHI, Toshiyuki [JP/JP]; (JP) (For US Only).
ISHIDA, Yohhei [JP/JP]; (JP) (For US Only)
Inventors: OHTA, Toshiharu; (JP).
NAKAYAMA, Kiyoshi; (JP).
OHTSUKA, Masami; (JP).
INAGAKI, Hiroaki; (JP).
NISHI, Toshiyuki; (JP).
ISHIDA, Yohhei; (JP)
Agent: IMAMURA, Masazumi; KRF Building, 5th floor, 5-5, Kyobashi 1-chome, Chuo-ku, Tokyo 104-0031 (JP)
Priority Data:
8/279172 22.10.1996 JP
8/287203 30.10.1996 JP
Title (EN) NOVEL REMEDIES FOR INFECTIOUS DISEASES
(FR) NOUVEAUX REMEDES POUR DES MALADIES INFECTIEUSES
Abstract: front page image
(EN)Novel compounds having three substituents in the cyclic partial structure thereof, such as a pyrrolidine or a benzene ring, for example, homophenylalanyl-trans-4-((S)-3-amino-2-hydroxypropionylamino)proline 5-indanylamide and N-(3-phenylpropyl)-3-((S)-2-hydroxy-3-aminopropionylamino)-5-(D-homophenylalanylamino)-benzamide. These compounds act on pathogenic microorganisms which have acquired tolerance to the existing antimicrobials and elevate the sensitivity to the antimicrobials, thus making them nontolerant. When used together with the antimicrobials, these compounds can efficaciously establish the prevention and/or treatment of microbial infectious diseases.
(FR)Nouveaux composés comportant trois substituants dans leur structure cyclique partielle, tels qu'une pyrrolidine ou un noyau benzénique, par exemple homophénylalanyl-trans-4-((S)-3-amino-2-hydroxypropionylamino)proline 5-indanylamide et N-(3-phénylpropyl)-3-((S)-2-hydroxy-3-aminopropionylamino)-5-(D- homophénylalanylamino)-benzamide. Ces composés ont une action sur des micro-organismes pathogènes qui ont développé une tolérance aux agents antimicrobiens existants et augmentent la sensibilité aux agents antimicrobiens, les rendant ainsi non tolérants. Lorsqu'ils sont utilisés avec les antimicrobiens, lesdits composés peuvent efficacement servir à la prévention et/ou au traitement de maladies infectieuses d'origine microbienne.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CU, CZ, EE, GE, HU, ID, IL, IS, JP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, SL, TR, TT, UA, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)