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Machine translation
1. (WO1998017267) COMPOSITIONS AND METHODS FOR TREATING BONE DEFICIT CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/017267    International Application No.:    PCT/US1997/018864
Publication Date: 30.04.1998 International Filing Date: 23.10.1997
Chapter 2 Demand Filed:    04.05.1998    
IPC:
A61K 31/196 (2006.01), A61K 31/4184 (2006.01), A61K 31/428 (2006.01), A61K 31/444 (2006.01), A61K 31/47 (2006.01), A61K 31/4709 (2006.01), A61K 31/498 (2006.01), A61K 31/517 (2006.01), A61K 31/53 (2006.01), A61K 31/655 (2006.01)
Applicants: ZYMOGENETICS, INC. [US/US]; 1201 Eastlake Avenue East, Seattle, WA 98102 (US) (For All Designated States Except US).
OSTEOSCREEN, INC. [US/US]; Suite 201, 2040 Babcock Road, San Antonio, TX 78229 (US) (For All Designated States Except US).
UNIVERSITY OF TEXAS AUSTIN [US/US]; 201 W. 7th Street, Austin, TX 78701 (US) (For All Designated States Except US).
ORME, Mark, W. [US/US]; (US) (For US Only).
BAINDUR, Nand [IN/US]; (US) (For US Only).
ROBBINS, Kirk, G. [US/US]; (US) (For US Only).
HARRIS, Scott, M. [US/US]; (US) (For US Only).
KONTOYIANNI, Maria [GR/US]; (US) (For US Only).
HURLEY, Laurence, H. [US/US]; (US) (For US Only).
KERWIN, Sean, M. [US/US]; (US) (For US Only).
MUNDY, Gregory, R. [US/US]; (US) (For US Only).
PETRIE, Charles [US/US]; (US) (For US Only)
Inventors: ORME, Mark, W.; (US).
BAINDUR, Nand; (US).
ROBBINS, Kirk, G.; (US).
HARRIS, Scott, M.; (US).
KONTOYIANNI, Maria; (US).
HURLEY, Laurence, H.; (US).
KERWIN, Sean, M.; (US).
MUNDY, Gregory, R.; (US).
PETRIE, Charles; (US)
Agent: MURASHIGE, Kate, H.; Morrison & Foerster LLP, 2000 Pennsylvania Avenue, N.W., Washington, DC 20006-1888 (US)
Priority Data:
08/736,318 23.10.1996 US
08/735,873 23.10.1996 US
08/735,881 23.10.1996 US
08/736,222 23.10.1996 US
08/736,221 23.10.1996 US
08/735,870 23.10.1996 US
08/735,876 23.10.1996 US
08/736,220 23.10.1996 US
08/736,319 23.10.1996 US
08/735,874 23.10.1996 US
08/736,228 23.10.1996 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING BONE DEFICIT CONDITIONS
(FR) COMPOSITIONS ET METHODES POUR TRAITER LES ETATS ASSOCIES A UN DEFICIT OSSEUX
Abstract: front page image
(EN)Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or 'linker' defined as including a covalent bond $i(per se) so as to space the aromatic systems at a distance 1.5-15Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.
(FR)Des composés qui contiennent deux systèmes aromatiques liés de manière covalente par un élément de liaison comprenant un ou plusieurs atomes, ou par un 'élément de liaison' défini comme comportant une liaison covalente $i(per se), qui écarte lesdits systèmes aromatiques d'une distance comprise entre 1,5 et 15 Å, sont efficaces pour traiter des états associés à un déficit osseux. Les composés peuvent être administrés à des vertébrés, seuls ou associés à des agents supplémentaires favorisant la croissance osseuse ou inhibant la résorption osseuse. Pour déterminer leur activité avant de les administrer, il est possible de les cribler en étudiant leur capacité à effectuer la transcription d'un gène marqueur couplé à un promoteur associé à une protéine morphogénétique osseuse, et/ou leur capacité à stimuler la croissance de la calotte crânienne dans les systèmes de modèles animaux.
Designated States: AL, AM, AU, BB, BG, BR, CA, CN, CZ, EE, FI, GE, HU, IL, IS, JP, KG, KP, KR, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, US, UZ, VN.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)