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1. (WO1998016519) [$g(v)-(2,3-DIHYDRO-1-BENZOXEPIN-4-YL)ALKYL]AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/016519    International Application No.:    PCT/JP1997/003672
Publication Date: 23.04.1998 International Filing Date: 14.10.1997
Chapter 2 Demand Filed:    12.05.1998    
IPC:
C07D 313/08 (2006.01)
Applicants: DAINIPPON PHARMACEUTICAL CO., LTD. [JP/JP]; 6-8, Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 541 (JP) (For All Designated States Except US).
MORIE, Toshiya [JP/JP]; (JP) (For US Only).
KANEHIRA, Aki [JP/JP]; (JP) (For US Only).
KAI, Naoki [JP/JP]; (JP) (For US Only).
HINO, Katsuhiko [JP/JP]; (JP) (For US Only).
KAWASHIMA, Katsuyoshi [JP/JP]; (JP) (For US Only).
SHIMIZU, Isao [JP/JP]; (JP) (For US Only).
AKIYAMA, Kazuhisa [JP/JP]; (JP) (For US Only)
Inventors: MORIE, Toshiya; (JP).
KANEHIRA, Aki; (JP).
KAI, Naoki; (JP).
HINO, Katsuhiko; (JP).
KAWASHIMA, Katsuyoshi; (JP).
SHIMIZU, Isao; (JP).
AKIYAMA, Kazuhisa; (JP)
Agent: YOSHIOKA, Takuji; Dainippon Pharmaceutical Co., Ltd., Tokyo Office, 2-5, Nihonbashi Honcho 2-chome, Chuo-ku, Tokyo 103 (JP)
Priority Data:
8/295837 16.10.1996 JP
Title (EN) [$g(v)-(2,3-DIHYDRO-1-BENZOXEPIN-4-YL)ALKYL]AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
(FR) DERIVES DE [$g(v)-(2,3-DIHYDRO-1-BENZOXEPIN-4-YL)ALKYL]AMINE, PROCEDE DE PREPARATION DE CES DERNIERS ET COMPOSITIONS MEDICAMENTEUSES CONTENANT CEUX-CI
Abstract: front page image
(EN)[$g(v)-(2,3-Dihydro-1-benzoxepin-4-yl)alkyl]amine derivatives represented by general formula (I), and salts and N-oxide derivatives thereof; a process for the preparation of them; and medicinal compositions containing the same as formula (I) (wherein R?1¿ and R?2¿ are each hydrogen, halogeno, alkyl, alkoxy or the like, or alternatively R?1¿ and R?2¿ may be united to form ethyleneoxy, trimethylene or the like; R?3¿ is hydrogen, alkyl or the like; R?4¿ is hydrogen, alkyl, acyl or the like, and R?5¿ is cycloalkyl, or alternatively R?4¿ and R?5¿ may form together with the adjacent nitrogen atom a cyclic amino group; and p is an integer of 2 to 6). The compounds exhibit a potent inhibitory activity against micturition reflex, being useful as remedies for pollakiuria and urinary incontinence.
(FR)La présente invention concerne des dérivés de [$g(v)-(2,3-dihydro-1-benzoxepin-4-yl)alkyl]amine représentés par la formule générale (I), ainsi que les sels et dérivés N-oxydes de ces derniers, un procédé de préparation de ceux-ci et des compositions médicamenteuses contenant ceux-ci. Dans cette formule R?1¿ et R?2¿, sont chacun un hydrogène, halogéno, alkyle, alkoxy ou analogue ou, selon une variante, R?1¿ et R?2¿ peuvent être liés pour former de l'éthylène-oxy, du triméthylène ou analogue; R?3¿ est un hydrogène, un alkyle ou analogue; R?4¿ est un hydrogène, un alkyle, acyle ou analogue et R?5¿ est un cycloalkyle, ou, selon une variante, R?4 ¿et R?5¿ peuvent former avec l'atome d'azote adjacent un groupe amino cyclique; et p est un entier de 2 à 6. Les composés de la présente invention sont dotés d'une puissante activité inhibitrice du réflexe de la miction, et sont par conséquent utilisés comme remèdes contre la pollakiurie et l'incontinence urinaire.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, ID, IL, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)