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1. (WO1998014579) RATH GENES AND POLYPEPTIDES AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF IMMUNE DISORDERS

Pub. No.:    WO/1998/014579    International Application No.:    PCT/US1997/018259
Publication Date: Apr 9, 1998 International Filing Date: Oct 6, 1997
IPC: A61K 38/00
A61K 48/00
C07K 14/47
Applicants: MILLENNIUM PHARMACEUTICALS, INC.
Inventors: LEVINSON, Douglas, A.
GIMENO, Carlos, J.
Title: RATH GENES AND POLYPEPTIDES AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF IMMUNE DISORDERS
Abstract:
The present invention relates, first, to the identification of novel nucleic acid molecules, termed RATH genes and RATH gene products encoded by such nucleic acid molecules, or degenerate variants, thereof, that participate in the regulation, control and/or modulation of G-protein-mediated signal transduction involved in T cell activation, including, but not limited to T helper (TH) cell and TH cell subpopulation activation. Specifically, the nucleic acid molecules of the present invention include the genes corresponding to the mammalian RATH genes, including the RATH1.1 genes. Sequence analysis indicates that the RATH genes are novel genes belonging to the RGS ('regulator of G-protein signalling') gene family, a gene family which encodes gene products involved in G-protein-mediated signal transduction.