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1. WO1998014197 - METHOD OF INHIBITING SMOOTH MUSCLE CELL PROLIFERATION

Publication Number WO/1998/014197
Publication Date 09.04.1998
International Application No. PCT/US1997/017526
International Filing Date 03.10.1997
Chapter 2 Demand Filed 30.04.1998
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/45 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
45Transferases (2)
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 9/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
CPC
A61K 31/70
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
45Transferases (2)
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C12N 2799/022
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2799Uses of viruses
02as vector
021for the expression of a heterologous nucleic acid
022where the vector is derived from an adenovirus
C12N 9/1205
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
Applicants
  • DUKE UNIVERSITY [US]/[US]
Inventors
  • KOCH, Walter, J.
  • LEFKOWITZ, Robert, J.
  • HAGEN, Per-Otto
Agents
  • WILSON, Mary, J.
Priority Data
60/027,77504.10.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF INHIBITING SMOOTH MUSCLE CELL PROLIFERATION
(FR) PROCEDE POUR INHIBER LA PROLIFERATION DE CELLULES DE MUSCLES LISSES
Abstract
(EN)
The present invention relates, in general, to vascular smooth muscle proliferation and, in particular, to a method of inhibiting arterial and venous smooth muscle proliferation resulting, for example, from arterial injury or vein grafting. The invention also relates to an expression construct encoding a G$g(b)$g(g) inhibitor suitable for use in such a method.
(FR)
La présente invention se rapporte, de manière générale, à la prolifération des cellules des muscles vasculaires lisses, à un procédé visant à inhiber la prolifération des muscles lisses veineux et artériels se manifestant, par exemple, à la suite d'une blessure artérielle ou d'une greffe de veine. L'invention se rapporte également à un produit d'expression recombiné codant un inhibiteur de G$g(b)$g(g) adapté à la mise en oeuvre dudit procédé.
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