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1. WO1998013508 - METHOD OF TARGETING MALIGNANT CELLS USING AN E2F RESPONSIVE PROMOTER

Publication Number WO/1998/013508
Publication Date 02.04.1998
International Application No. PCT/US1997/017143
International Filing Date 24.09.1997
Chapter 2 Demand Filed 15.04.1998
IPC
C12N 9/12 2006.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
C12N 15/861 2006.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
861Adenoviral vectors
CPC
C12N 15/86
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C12N 2710/10343
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2710dsDNA Viruses
00011dsDNA Viruses
10011Adenoviridae
10311Mastadenovirus, e.g. human or simian adenoviruses
10341Use of virus, viral particle or viral elements as a vector
10343viral genome or elements thereof as genetic vector
C12N 2830/008
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2830Vector systems having a special element relevant for transcription
008cell type or tissue specific enhancer/promoter combination
C12N 9/1211
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
1211Thymidine kinase (2.7.1.21)
Applicants
  • DANA-FARBER CANCER INSTITUTE [US]/[US] (AllExceptUS)
  • FINE, Howard, A. [US]/[US] (UsOnly)
  • KAELIN, William, Jr. [US]/[US] (UsOnly)
Inventors
  • FINE, Howard, A.
  • KAELIN, William, Jr.
Agents
  • EISENSTEIN, Ronald, I.
Priority Data
60/026,95924.09.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF TARGETING MALIGNANT CELLS USING AN E2F RESPONSIVE PROMOTER
(FR) METHODE DE CIBLAGE DES CELLULES MALIGNES AU MOYEN D'UN PROMOTEUR REAGISSANT AU FACTEUR E2F
Abstract
(EN)
A method of selectively expressing a gene in a malignant as opposed to a non-malignant cell is taught. This permits one to selectively express proteins that would be deletorious to normal cells with minimal harm. The method involves the use of a nucleic acid cassette having an E2F responsive promoter operably linked to a gene of interest, which encodes either a positive or negative potentiator such as antibodies, dominant negative mutants, suicide genes, antisense RNA, ribozymes and cytotoxic agents.
(FR)
Méthode d'expression sélective d'un gène dans une cellule maligne, par opposition à une cellule bénigne, permettant d'exprimer sélectivement les protéines qui seraient dommageables à des cellules normales. Cette méthode, dont les effets nuisibles sont minimes, consiste à utiliser une cassette d'acide nucléique présentant un promoteur réagissant au facteur E2F et lié fonctionnellement à tel ou tel gène considéré, qui code un potentialisateur positif ou négatif tel que des anticorps, des mutants négatifs dominants, des gènes suicide, l'ARN antisense, un ribozyme et des agents cytotoxiques.
Also published as
US09269321
Latest bibliographic data on file with the International Bureau