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1. WO1998007452 - METHOD OF STERILISING MATERIAL FOR IMPLANTATION

Publication Number WO/1998/007452
Publication Date 26.02.1998
International Application No. PCT/GB1997/002265
International Filing Date 21.08.1997
IPC
A61L 2/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
A61L 2/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
16using chemical substances
20Gaseous substances, e.g. vapours
A61L 27/36 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
CPC
A61L 2/0094
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
0005for pharmaceuticals, biologicals or living parts
0082using chemical substances
0094Gaseous substances
A61L 2/206
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
16using chemical substances
20Gaseous substances, e.g. vapours
206Ethylene oxide
A61L 27/3625
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3604characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
3625Vascular tissue, e.g. heart valves
A61L 27/3683
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3683subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
Applicants
  • SULZER VASCUTEK LIMITED [GB]/[GB] (AllExceptUS)
  • WALKER, Donald, Francis [GB]/[GB] (UsOnly)
Inventors
  • WALKER, Donald, Francis
Agents
  • MURGITROYD & COMPANY
Priority Data
9617509.621.08.1996GB
9712503.317.06.1997GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF STERILISING MATERIAL FOR IMPLANTATION
(FR) PROCEDE DE STERILISATION DE MATIERES DESTINEES A L'IMPLANTATION
Abstract
(EN) A method of sterilising material is disclosed, the material being for implantation into a human or animal body. The method includes treating the material with a substance non-reactive with a sterilising agent to be used, the substance being selected so as to maintain certain physical characteristics of the material such as flexibility and/or structure of cells or extra cellular material. Suitable substances include water soluble non-volatile substances for example glycerol. The method can be used on graphs for implantation or on biological material such as vascular tissue etc. and has the advantage that the substance does not react with water and so the material can be treated in solution without drying out or becoming brittle.
(FR) Cette invention concerne un procédé de stérilisation de matières destinées à l'implantation dans un corps humain ou animal. Ledit procédé consiste à traiter une telle matière avec une substance ne réagissant pas avec l'agent de stérilisation devant être utilisé, ladite substance étant sélectionnée de manière à préserver certaines caractéristiques de la matière telle que sa flexibilité et/ou la structure de ses cellules ou de la matière extra-cellulaire. Les substances non volatiles solubles dans l'eau telles que le glycérol constituent des substances appropriées. Ledit procédé peut être mis en oeuvre sur des greffons destinés à l'implantation ou sur une matière biologique du type tissu vasculaire. Il est avantageux en ce que la substance ne réagit pas avec l'eau et il permet de ce fait de traiter ladite matière en solution sans que celle-ci sèche ou devienne cassante.
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