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1. (WO1998003684) METHOD FOR SEQUENCING NUCLEIC ACIDS USING MATRIX-ASSISTED LASER DESORPTION IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/003684 International Application No.: PCT/US1997/012688
Publication Date: 29.01.1998 International Filing Date: 19.07.1997
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: HYBRIDON, INC.[US/US]; 620 Memorial Drive Cambridge, MA 02139, US
Inventors: WANG, Bing, H.; US
COHEN, Aharon, S.; US
Agent: KEOWN, Wayne, A. ; Hale and Dorr LLP 60 State Street Boston, MA 02109, US
Priority Data:
08/683,88019.07.1996US
60/048,61004.06.1997US
null19.07.1997US
Title (EN) METHOD FOR SEQUENCING NUCLEIC ACIDS USING MATRIX-ASSISTED LASER DESORPTION IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY
(FR) PROCEDE DE SEQUENÇAGE D'ACIDES NUCLEIQUES UTILISANT LA SPECTROMETRIE DE MASSE MATRICIELLE DES TEMPS DE VOL D'IONISATION OU DE DESORPTION PAR LASER
Abstract:
(EN) The invention provides an analytical method for determining the nucleotide sequence of nucleic acid analytes, including chemically modified oligonucleotides. This new method utilizes matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) with delayed pulsed ion extraction.
(FR) La présente invention concerne un procédé analytique permettant de déterminer la séquence des analytes acides nucléiques des nucléotides, y compris les oligonucléotides chimiquement modifiés. Ce nouveau procédé utilise la spectrométrie de masse matricielle des temps de vol d'ionisation ou de désorption par laser ou 'MALDI-TOFMS' (pour $i('Matrix-Assisted Laser Desorption/Ionization - Time-Of-Flight Mass Spectrometry')) à extraction à retard d'ions pulsés.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)