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1. (WO1998003653) METHOD FOR PREPARING TRANSGENIC NON-HUMAN MAMMALIAN ORGANS FOR TRANSPLANTATION TO HUMANS, AND NUCLEOTIDE SEQUENCES THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/003653 International Application No.: PCT/FR1997/001340
Publication Date: 29.01.1998 International Filing Date: 18.07.1997
Chapter 2 Demand Filed: 02.12.1997
IPC:
A01K 67/027 (2006.01) ,C07K 16/28 (2006.01) ,C12N 15/85 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
Applicants: VANHOVE, Bernard[BE/FR]; FR (UsOnly)
POURCEL, Christine[FR/FR]; FR (UsOnly)
SOULILLOU, Jean-Paul[FR/FR]; FR (UsOnly)
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)[FR/FR]; 101, rue de Tolbiac F-75654 Paris Cedex 13, FR (AllExceptUS)
Inventors: VANHOVE, Bernard; FR
POURCEL, Christine; FR
SOULILLOU, Jean-Paul; FR
Agent: DEMACHY, Charles ; Grosset-Fournier & Demachy S.A.R.L. 103, rue La Fayette F-75481 Paris Cedex 10, FR
Priority Data:
96/0907719.07.1996FR
Title (EN) METHOD FOR PREPARING TRANSGENIC NON-HUMAN MAMMALIAN ORGANS FOR TRANSPLANTATION TO HUMANS, AND NUCLEOTIDE SEQUENCES THEREFOR
(FR) PROCEDE DE PREPARATION D'ORGANES DE MAMMIFERES NON HUMAINS TRANSGENIQUES EN VUE DE LEUR TRANSPLANTATION CHEZ L'HOMME, ET SEQUENCES NUCLEOTIDIQUES POUR LA MISE EN OEUVRE DE CE PROCEDE
Abstract:
(EN) The use of nucleotide sequences coding for antibodies to any molecule involved in a graft versus host reaction (hereinafter anti-molecule antibodies), for preparing transgenic cells or organs of non-human mammals, wherein said molecules at least partially form immune complexes with said anti-molecule antibodies, such that the activity of said molecules in graft versus host reactions is at least partially inhibited, said transgenic cells or organs of non-human mammals being intended for transplantation into a patient, is disclosed.
(FR) L'invention a pour objet l'utilisation de séquences nucléotidiques codant pour des anticorps dirigés contre toute molécule impliquée dans un phénomène de rejet de greffe (encore désignés ci-après anticorps anti-molécules), pour la préparation de cellules transgéniques, ou organes transgéniques, de mammifères non humains, au sein desquels lesdites molécules forment en totalité ou en partie des complexes immuns avec lesdits anticorps anti-molécules, de telle sorte que l'activité desdites molécules dans les phénomènes de rejet de greffe soit totalement ou partiellement inhibée, lesdites cellules ou lesdits organes transgéniques de mammifères non humains étant destinés à être greffés chez un patient.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)