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1. (WO1998003646) COMPOSITIONS AND METHODS FOR TREATING SPECIFIC GENE EXPRESSION-RELATED DISEASES AND DISORDERS IN HUMANS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/003646 International Application No.: PCT/US1996/012056
Publication Date: 29.01.1998 International Filing Date: 22.07.1996
IPC:
A61K 38/00 (2006.01) ,C12N 15/11 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants: HYBRIDON, INC.[US/US]; One Innovation Drive Worcester, MA 01605, US
Inventors: SCHECHTER, Paul, J.; US
MARTIN, B., Russel; US
TOURNERIE, Christophe; FR
AGRAWAL, Sudhir; US
Agent: KERNER, Ann-Louise ; Hale & Dorr 60 State Street Boston, MA 02109, US
Priority Data:
Title (EN) COMPOSITIONS AND METHODS FOR TREATING SPECIFIC GENE EXPRESSION-RELATED DISEASES AND DISORDERS IN HUMANS
(FR) COMPOSITIONS ET PROCEDES THERAPEUTIQUES POUR LE TRAITEMENT CHEZ L'HOMME DE MALADIES OU DE TROUBLES LIES A L'EXPRESSION DE GENES SPECIFIQUES
Abstract:
(EN) The present invention provides therapeutic compositions and methods for treating humans suffering from diseases or disorders caused by cellular expression of aberrant exogenous genes or aberrant endogenous genes comprising administering to the human a therapeutically effective amount of a composition of the invention comprising an oligonucleotide capable of specifically down-regulating the expression of such a gene.
(FR) L'invention concerne des compositions et des procédés thérapeutiques pour traiter un homme souffrant de maladies ou de troubles dûs à l'expression cellulaire de gènes exogènes aberrants, ou de gènes endogènes aberrants, consistant à administrer au patient une dose à effet thérapeutique d'une composition selon l'invention, comprenant un oligonucléotide capable d'abaisser spécifiquement l'expression d'un gel gène.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)