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Machine translation
1. (WO1998003643) TRANSGENIC ANIMALS WITH MUTANT HUMAN APP OR A4CT SEQUENCES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/003643    International Application No.:    PCT/EP1997/003960
Publication Date: 29.01.1998 International Filing Date: 17.07.1997
Chapter 2 Demand Filed:    19.01.1998    
IPC:
C07K 14/47 (2006.01), C12N 15/85 (2006.01)
Applicants: SMITHKLINE BEECHAM PHARMA GMBH [DE/DE]; Leopoldstrasse 175, D-80804 Munich (DE) (For All Designated States Except US).
SMITHKLINE BEECHAM AUSTRALIA PTY. LTD. [AU/AU]; 300 Frankston Road, Dandenong, VIC 3175 (AU) (For All Designated States Except US).
LICHTENTHALER, Stefan [DE/DE]; (DE) (For US Only).
PRIOR, Peter [DE/DE]; (DE) (For US Only).
MASTERS, Colin, Louis [AU/AU]; (AU) (For US Only).
BEYREUTHER, Konrad [DE/DE]; (DE) (For US Only)
Inventors: LICHTENTHALER, Stefan; (DE).
PRIOR, Peter; (DE).
MASTERS, Colin, Louis; (AU).
BEYREUTHER, Konrad; (DE)
Agent: VALENTINE, Jill; SmithKline Beecham, Corporate Intellectual Property, Two New Horizons Court, Brentford, Middlesex TW8 9EP (GB).
GIDDINGS, Peter, John; SmithKline Beecham p.l.c., Two New Horizons Court, Brentford, Middlesex TW8 9EP (GB)
Priority Data:
9615351.5 22.07.1996 GB
9618804.0 09.09.1996 GB
9709239.9 08.05.1997 GB
Title (EN) TRANSGENIC ANIMALS WITH MUTANT HUMAN APP OR A4CT SEQUENCES
(FR) ANIMAUX TRANSGENIC AVEC SEQUENCES APP OU A4CT MUTANTES HUMAINES
Abstract: front page image
(EN)Constructs comprising a human APP or A4CT DNA sequence encoding mutations which lead to a higher ratio of $g(b)A41-42/$g(b)A41-40 than wild type and their use in the production of transgenic animals developing amyloid plaques as a model of Alzheimer's disease.
(FR)Produits de recombinaison qui comportent une séquence d'ADN APP ou A4CT codant des mutations qui entraînent un taux plus élevé de $g(b)A41-42/$g(b)A41-40 que le type sauvage et utilisation desdits produits dans la production d'animaux transgéniques développant des plaques amyloïdes, destinés à servir de modèles pour la maladie d'Alzheimer.
Designated States: JP, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)