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1. (WO1998003551) CD6 LIGAND
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/003551 International Application No.: PCT/US1997/012511
Publication Date: 29.01.1998 International Filing Date: 17.07.1997
IPC:
C07K 14/705 (2006.01) ,C07K 16/28 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants: DUKE UNIVERSITY[US/US]; 230 North Building Research Drive Durham, NC 27708-0083, US
BRISTOL-MYERS SQUIBB COMPANY[US/US]; 345 Park Avenue New York, NY 10154, US
Inventors: HAYNES, Barton, F.; US
ARUFFO, Alejandro; US
PATEL, Dhavalkumar; US
BOWEN, Michael, A.; US
MARQUARDT, Hans; US
SIADAK, Anthony, W.; US
Agent: WILSON, Mary, J.; Nixon & Vanderhye P.C. 8th floor 1100 North Glebe Road Arlington, VA 22201-4714, US
Priority Data:
08/684,59418.07.1996US
Title (EN) CD6 LIGAND
(FR) LIGAND DE CD6
Abstract:
(EN) The present invention relates, in general, to CD6 and, in particular, to a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cell types. The invention further relates to methods of inhibiting the interaction of CD6 and the CD6 ligand, and to methods of screening compounds for their ability to inhibit that interaction. The invention also relates to antibodies, and binding fragments thereof, specific for CD6 ligand.
(FR) La présente invention concerne en général les CD6 et plus particulièrement un ligand des CD6 présent superficiellement sur les cellules épithéliales du thymus, sur les monocytes, sur les lymphocytes T activés et sur divers autres types de cellules. L'invention concerne également, non seulement des procédés d'inhibition de l'interaction entre CD6 et le ligand des CD6, mais également des procédés de sélection de composés en fonction de leur aptitude à inhiber cette interaction. L'invention concerne enfin des anticorps ainsi que des fragments de liaison de ces anticorps, spécifiques du ligand des CD6.
Designated States: CA, JP
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)