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Machine translation
1. (WO1998003195) METHODS AND COMPOSITIONS FOR MODULATION OF GROWTH RESPONSE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/003195    International Application No.:    PCT/US1997/012498
Publication Date: 29.01.1998 International Filing Date: 18.07.1997
Chapter 2 Demand Filed:    18.02.1998    
IPC:
A61K 38/17 (2006.01), A61K 48/00 (2006.01), G01N 33/574 (2006.01)
Applicants: ARCH DEVELOPMENT CORPORATION [US/US]; 1101 East 58th Street, Chicago, IL 60637 (US) (For All Designated States Except US).
DANA-FARBER CANCER INSTITUTE [US/US]; 44 Binney Street, Boston, MA 02115 (US) (For All Designated States Except US).
KUFE, Donald, W. [US/US]; (US) (For US Only).
YUAN, Zhi-Min [CN/US]; (US) (For US Only).
WEICHSELBAUM, Ralph, R. [US/US]; (US) (For US Only)
Inventors: KUFE, Donald, W.; (US).
YUAN, Zhi-Min; (US).
WEICHSELBAUM, Ralph, R.; (US)
Agent: HIGHLANDER, Steven, L.; Arnold, White & Durkee, P.O. Box 4433, Houston, TX 77210 (US)
Priority Data:
60/022,124 18.07.1996 US
Title (EN) METHODS AND COMPOSITIONS FOR MODULATION OF GROWTH RESPONSE
(FR) PROCEDES ET COMPOSITIONS DE MODULATION DU TAUX DE CROISSANCE
Abstract: front page image
(EN)The present invention details methods for the treatment of cancer. In particular, it concerns the induction of apoptosis of cancer cells following treatment with c-Abl and p300, which control levels of wild-type p53. Also included are methods of combination therapy wherein cells lacking p53 are supplemented with c-Abl, p300 and wild-type p53 to induce an apoptotic responses.
(FR)La présente invention, qui concerne des thérapies anticancéreuses, concerne plus particulièrement l'induction d'une apoptose des cellules cancéreuses à la suite d'une thérapie par c-Abl et p300 permettant de contrôler le niveau des p53 de type sauvage. L'invention concerne également un traitement associé consistant à apporter, aux cellules déficientes en p53, des c-Abl, p300 et p53 de type sauvage de façon à induire des réponses apoptotiques.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)