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1. (WO1998002530) PRODUCTION OF ATTENUATED RESPIRATORY SYNCYTIAL VIRUS VACCINES FROM CLONED NUCLEOTIDE SEQUENCES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/002530    International Application No.:    PCT/US1997/012269
Publication Date: 22.01.1998 International Filing Date: 15.07.1997
Chapter 2 Demand Filed:    09.02.1998    
IPC:
A61K 39/00 (2006.01), C07K 14/135 (2006.01), C12N 7/04 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Box OTT, Bethesda, MD 20892 (US) (For All Designated States Except US).
MURPHY, Brian, R. [US/US]; (US) (For US Only).
COLLINS, Peter, L. [US/US]; (US) (For US Only).
WHITEHEAD, Stephen, S. [US/US]; (US) (For US Only).
BUKREYEV, Alexander A. [RU/US]; (US) (For US Only).
JUHASZ, Katalin [HU/US]; (US) (For US Only).
TENG, Michael, N. [US/US]; (US) (For US Only)
Inventors: MURPHY, Brian, R.; (US).
COLLINS, Peter, L.; (US).
WHITEHEAD, Stephen, S.; (US).
BUKREYEV, Alexander A.; (US).
JUHASZ, Katalin; (US).
TENG, Michael, N.; (US)
Agent: PARMELEE, Steven, W.; Townsend and Townsend and Crew LLP, 8th floor, Two Embarcadero Center, San Francisco, CA 94111-3834 (US)
Priority Data:
60/021,773 15.07.1996 US
60/046,141 09.05.1997 US
60/047,634 23.05.1997 US
Title (EN) PRODUCTION OF ATTENUATED RESPIRATORY SYNCYTIAL VIRUS VACCINES FROM CLONED NUCLEOTIDE SEQUENCES
(FR) PRODUCTION DE VACCINS A BASE DE VIRUS RESPIRATOIRE SYNCYTIAL ATTENUE, A PARTIR DE SEQUENCES NUCLEOTIDIQUES CLONEES
Abstract: front page image
(EN)Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. Alternatively, recombinant RSV and vaccine compositions thereof incorporate attenuating and other mutations specifying desired structural and or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of a selected nucleotide sequence, gene, or gene segment in an infectious RSV clone. The immune system of an individual is stimulated to induce protection against natural RSV infection, or multivalently against infection by RSV and another pathogen, such as PIV, by administration of attenuated, biologically derived or recombinant RSV.
(FR)On produit un virus respiratoire syncytial (VRS) et des compositions vaccinales à base dudit virus en introduisant des mutations spécifiques associées à des phénotypes atténuants dans le type sauvage ou VRS. Celui-ci est incomplètement atténué soit par passage au froid, soit par introduction de mutations qui donnent des virus ayant un phénotype sensible à la température (ts) ou adapté au froid (ca). Le VRS recombinant et ses compositions vaccinales peuvent également introduire dans un VRS infectieux des mutations atténuantes ou d'autres mutations spécifiant ses caractéristiques structurelles ou phénotypiques. Le VRS recombinant incorpore les mutations désirées spécifiées par insertion, délétion, substitution ou réarrangement d'une séquence de nucléotides, d'un gène ou d'un segment de gène sélectionné, dans un clone de VRS infectieux. Le système immunitaire d'un individu est stimulé de façon à induire une protection contre l'infection à VRS naturel, ou, de manière plurivalente, contre l'infection à VRS et un autre pathogène, tel le virus para-influenza, par l'administration d'un VRS atténué, biologiquement dérivé ou recombinant.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)