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Machine translation
1. (WO1998002525) PITUITARY DIFFERENTIATION FACTOR AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/002525    International Application No.:    PCT/US1997/011971
Publication Date: 22.01.1998 International Filing Date: 09.07.1997
Chapter 2 Demand Filed:    29.01.1998    
IPC:
A61K 38/00 (2006.01), C07K 14/575 (2006.01)
Applicants: HOLLAND, James, F. [US/US]; (US)
Inventors: HOLLAND, James, F.; (US).
PLATICA, Micsunica; (US).
PLATICA, Ovidiu; (US)
Agent: CLARK, Richard, S.; Brumbaugh, Graves, Donohue & Raymond, 30 Rockefeller Plaza, New York, NY 10012 (US)
Priority Data:
60/021,589 11.07.1996 US
Title (EN) PITUITARY DIFFERENTIATION FACTOR AND METHODS OF USE THEREOF
(FR) FACTEUR DE DIFFERENCIATION HYPOPHYSAIRE ET SES PROCEDES D'UTILISATION
Abstract: front page image
(EN)The present invention is directed to pituitary differentiation factor (PDF), a pituitary factor that is capable of differentiating cells including breast cancer and prostatic cancer cells. Isolated nucleic acids encoding PDF and related vectors and host cells are also provided. Restoration of differentiating ability to malignantly transformed cells provides a modality of cancer therapy. The isolated and purified PDF of the invention is accordingly useful in the treatment of breast and prostatic cancer.
(FR)L'invention porte sur le facteur de différenciation hypophysaire (PDF) capable de différencier des cellules dont les cellules cancéreuses du sein ou de la prostate. L'invention porte également sur des acides nucléiques isolés codant pour le PDF et les vecteurs et cellules hôtes associés. La restauration de la capacité de différenciation de cellules devenues malignes est l'une des modalités de la thérapie du cancer. Le PDF isolé et purifié objet de l'invention s'avère pour ces raisons utile dans la thérapie du cancer du sein et de la prostate.
Designated States: AU, CA, JP.
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)