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Machine translation
1. (WO1998002461) LIQUID PHASE PEPTIDE SYNTHESES OF KL-4 PULMONARY SURFACTANT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/002461    International Application No.:    PCT/US1997/012163
Publication Date: 22.01.1998 International Filing Date: 11.07.1997
Chapter 2 Demand Filed:    09.02.1998    
IPC:
A61K 38/00 (2006.01), C07K 1/12 (2006.01), C07K 14/785 (2006.01)
Applicants: ORTHO PHARMACEUTICAL CORPORATION [US/US]; Route #202, P.O. Box 300, Raritan, NJ 08869-0602 (US)
Inventors: ABDEL-MAGID, Ahmed, F.; (US).
EGGMANN, Urs; (CH).
MARYANOFF, Cynthia, Anne; (US).
THALER, Adrian; (CH).
VILLANI, Frank, J.; (US)
Agent: CIAMPORCERO, Audley, A., Jr.; Johnson and Johnson, One Johnson & Johnson Plaza, New Brunswick, NJ 08933 (US)
Priority Data:
60/021,455 17.07.1996 US
Title (EN) LIQUID PHASE PEPTIDE SYNTHESES OF KL-4 PULMONARY SURFACTANT
(FR) SYNTHESES DE PEPTIDES EN PHASE LIQUIDE DU SURFACTANT PULMONAIRE KL-4
Abstract: front page image
(EN)The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu¿4?)¿4?-Lys, of the pulmonary surfactant KL-4. These processes are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the $g(a)-carbon.
(FR)L'invention concerne des procédés perfectionnés en phase liquide pour la préparation de la fraction protéinique de 21 résidus, (Lys-Leu¿4?)¿4?-Lys, du surfactant pulmonaire KL-4. Ces procédés peuvent faire l'objet d'une synthèse à large échelle et un procédé consiste à soumettre un ester à une saponification, ce qui réduit la racémisation inhérente de l'$g(a)-carbone.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)