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Machine translation
1. (WO1998002412) PROPIONANILIDE DERIVATIVES OR SALTS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/002412    International Application No.:    PCT/JP1997/002385
Publication Date: 22.01.1998 International Filing Date: 10.07.1997
Chapter 2 Demand Filed:    24.09.1997    
IPC:
C07C 237/04 (2006.01), C07C 309/73 (2006.01), C07C 311/06 (2006.01), C07C 311/13 (2006.01), C07C 311/19 (2006.01), C07C 311/29 (2006.01), C07C 311/46 (2006.01), C07D 317/58 (2006.01)
Applicants: YAMANOUCHI PHARMACEUTICAL CO., LTD. [JP/JP]; 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo 103 (JP) (For All Designated States Except US).
SUGA, Akira [JP/JP]; (JP) (For US Only).
MATSUDA, Koyo [JP/JP]; (JP) (For US Only).
MIYAUCHI, Hiromi [JP/JP]; (JP) (For US Only).
INAGAKI, Osamu [JP/JP]; (JP) (For US Only)
Inventors: SUGA, Akira; (JP).
MATSUDA, Koyo; (JP).
MIYAUCHI, Hiromi; (JP).
INAGAKI, Osamu; (JP)
Agent: NAGAI, Shozo; Yamanouchi Pharmaceutical Co., Ltd., Patent & Information Dept., 17-1, Hasune 3-chome, Itabashi-ku, Tokyo 174-8612 (JP)
Priority Data:
8/183070 12.07.1996 JP
Title (EN) PROPIONANILIDE DERIVATIVES OR SALTS THEREOF
(FR) DERIVES DE PROPIONANILIDE OU SELS DE CEUX-CI
Abstract: front page image
(EN)Propionanilide derivatives of general formula (I) or pharmaceutically acceptable salts thereof; and drug compositions useful as an ACAT inhibitor or the like and comprising the derivatives or salts and pharmaceutically acceptable carriers. In the said formula, the symbols have the following meanings: A: an aryl or 5- or 6-membered heterocyclic group, R?1¿ and R?2¿: each lower alkyl, R?3¿: hydrogen or lower alkyl, B: a bond, lower alkylene, lower alkenylene, lower alkynylene, or -S(O)¿n?- wherein n is 0, 1 or 2, and R?4¿: alkyl, aralkyl, carboxyl, lower alkoxycarbonyl, cycloalkyl, or aryl such as pyridyl.
(FR)L'invention concerne des dérivés de propionanilide de formule générale I ou des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des compositions médicamenteuses utiles en tant qu'inhibiteur D'ACAT ou similaire et comprenant lesdits dérivés ou sels ainsi que des excipients pharmaceutiquement acceptables. Dans ladite formule (I), les symboles ont les significations suivantes: A représente un groupe hétérocyclique à 5 ou 6 éléments ou aryle; R?1¿ et R?2¿ représentent chacun alkyle inférieur; R?3¿ représente hydrogène ou alkyle inférieur; B représente une liaison, alkylène inférieur, alcénylène inférieur, alcynylène inférieur ou -S(O)¿n?-, n valant 0, 1 ou 2; et R?4¿ représente alkyle, aralkyle, carboxyle, alcoxycarbonyle inférieur, cycloalkyle ou aryle tel que pyridyle.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, GH, HU, IL, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, RO, RU, SD, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)