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1. (WO1998002036) ANIMAL MODEL KNOCK-OUT FOR A NEURONAL INTERMEDIATE FILAMENT PROTEIN
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/002036 International Application No.: PCT/CA1997/000493
Publication Date: 22.01.1998 International Filing Date: 15.07.1997
Chapter 2 Demand Filed: 16.02.1998
IPC:
C07K 14/47 (2006.01) ,C12N 15/85 (2006.01)
Applicants: JULIEN, Jean-Pierre[CA/CA]; CA
ZHU, Qinzhang[CA/CA]; CA
Inventors: JULIEN, Jean-Pierre; CA
ZHU, Qinzhang; CA
Agent: MBM & CO.; P.O. Box 809 Station B Ottawa, Ontario K1P 5P9, CA
Priority Data:
08/683,60115.07.1996US
Title (EN) ANIMAL MODEL KNOCK-OUT FOR A NEURONAL INTERMEDIATE FILAMENT PROTEIN
(FR) RECOMBINAISON HOMOLOGUE POUR MODELE ANIMAL PRESENTANT DES TAUX REDUITS OU UNE ELIMINATION DE LA PROTEINE DE FILAMENTS INTERMEDIAIRES NEURONAUX
Abstract:
(EN) (57) Abstract Transgenic non-human mammals and methods of preparing such mammals are disclosed. Homologous recombination is employed to inactivate genes, particularly genes coding for neuronal intermediate filaments. These animals, whose phenotype is characterized by reduced or eliminated levels of a neuronal intermediate filament, are useful as models for studying aging, injury to the nervous system, and pathogenesis of neurodegenerative diseases. They are also useful for the screening of potential therapeutic agents.
(FR) Mammifères non humains transgéniques et procédés de préparation desdits mammifères. On emploie la recombinaison homologue pour inactiver des gènes, en particulier des gènes codant les filaments intermédiaires neuronaux. Ces animaux, dont le phénotype est caractérisé par des taux réduits ou nuls de filaments intermédiaires neuronaux, sont utiles en tant que modèles pour étudier le vieillissement, les lésions du système nerveux central et la pathogenèse des maladies neurodégénératives. Ils sont également utiles pour le criblage d'agents thérapeutiques potentiels.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)