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Machine translation
1. (WO1998001460) BRCA1 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF BREAST CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/001460    International Application No.:    PCT/US1997/011946
Publication Date: 15.01.1998 International Filing Date: 08.07.1997
Chapter 2 Demand Filed:    09.02.1998    
IPC:
A61K 38/00 (2006.01), C07K 14/47 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street, Austin, TX 78701 (US) (For All Designated States Except US).
LEE, Wen-Hwa [US/US]; (US) (For US Only).
CHEN, Yumay [--/US]; (US) (For US Only).
CHEN, Chi-Fen [--/US]; (US) (For US Only).
CHEN, Phang-Lang [--/US]; (US) (For US Only).
FARMER, Andrew, A. [US/US]; (US) (For US Only).
JONES, Diane, C. [US/US]; (US) (For US Only).
ALLRED, D., Craig [US/US]; (US) (For US Only).
OSBORNE, C., Kent [US/US]; (US) (For US Only)
Inventors: LEE, Wen-Hwa; (US).
CHEN, Yumay; (US).
CHEN, Chi-Fen; (US).
CHEN, Phang-Lang; (US).
FARMER, Andrew, A.; (US).
JONES, Diane, C.; (US).
ALLRED, D., Craig; (US).
OSBORNE, C., Kent; (US)
Agent: KITCHELL, Barbara, S.; Arnold, White & Durkee, P.O. Box 4433, Houston, TX 77210 (US)
Priority Data:
60/015,863 08.07.1996 US
Title (EN) BRCA1 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF BREAST CANCER
(FR) COMPOSITIONS BRCA1 ET PROCEDES DE DIAGNOSTIC ET DE TRAITEMENT DU CANCER DU SEIN
Abstract: front page image
(EN)Disclosed are methods and compositions relating to the diagnosis and treatment of breast and related cancers. Compositions and methods for the detection of the BRCA1 gene product $i(in vivo) and $i(in vitro) are disclosed, as well as methods for diagnosing aberrant localization of BRCA1 protein in cells using anti-BRCA1 antibodies. Also disclosed are methods for identifying BRCA1-associated proteins which function in the proper translocation of the BRCA1 gene product to the cell nucleus.
(FR)L'invention concerne des procédés et des compositions s'appliquant au diagnostic et au traitement du cancer du sein et autres cancers apparentés. L'invention concerne également des compositions et des procédés de détection du produit génique BRCA1 $i(in vivo) et $i(in vitro), ainsi que des procédés de diagnostic de localisation aberrante de la protéine BRCA1 dans des cellules mettant en oeuvre des anticorps anti-BRCA1. L'invention concerne de plus des procédés d'identification des protéines associées à BRCA1 qui agissent dans la translocation correcte du produit génique BRCA1 vers le noyau cellulaire.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)