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Pub. No.:    WO/1998/000443    International Application No.:    PCT/GB1997/001575
Publication Date: 08.01.1998 International Filing Date: 11.06.1997
Chapter 2 Demand Filed:    30.11.1997    
A61K 38/00 (2006.01), C07K 5/06 (2006.01), C07K 14/815 (2006.01)
Applicants: TRIGEN LIMITED [GB/GB]; 20 St. James's Street, London SW1A 1ES (GB) (For All Designated States Except US).
DEADMAN, John, Joseph [GB/GB]; (GB) (For US Only).
ELGENDY, Said [EG/GB]; (GB) (For US Only).
GREEN, Donovan [GB/GB]; (GB) (For US Only).
SKORDALAKES, Emmanuel [GR/GB]; (GB) (For US Only).
SCULLY, Michael, Finbarr [GB/GB]; (GB) (For US Only).
GOODWIN, Christopher, Andrew [GB/GB]; (GB) (For US Only).
KAKKAR, Vijay, Vir [IN/GB]; (GB) (For US Only)
Inventors: DEADMAN, John, Joseph; (GB).
ELGENDY, Said; (GB).
GREEN, Donovan; (GB).
SKORDALAKES, Emmanuel; (GB).
SCULLY, Michael, Finbarr; (GB).
GOODWIN, Christopher, Andrew; (GB).
KAKKAR, Vijay, Vir; (GB)
Agent: GILHOLM, S.P.; Harrison Goddard Foote, Belmont House, 20 Wood Lane, Leeds LS6 2AE (GB)
Priority Data:
9613718.7 29.06.1996 GB
Abstract: front page image
(EN)Bifunctional peptide thrombin inhibitors and methods of their manufacture are provided. The inhibitors have an anion-binding exosite associating moiety joined to a catalytic site directed moiety. A spacer peptide and a non-peptide linker moiety enable both the anion-binding exosite associating moiety and the catalytic site directed moiety to bind simultaneously to a thrombin molecule thereby permitting the treatment of thrombosis.
(FR)L'invention concerne des inhibiteurs peptidiques bifonctionnels de thrombine et leurs procédés de fabrication. Ces inhibiteurs possèdent une fraction d'association à l'exosite de fixation d'anions reliée à une fraction dirigée catalytique. Un peptide espaceur et une fraction de séquence de liaison non peptidique permettent à la fois à la fraction d'association à l'exosite de fixation d'anions et à la fraction dirigée catalytique de se lier simultanément à une molécule de thrombine, facilitant ainsi le traitement de la thrombose.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)