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1. (WO1998000116) ORAL COMPOSITION COMPRISING A TRIAZOLE ANTIFUNGAL COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/000116    International Application No.:    PCT/US1997/010122
Publication Date: 08.01.1998 International Filing Date: 25.06.1997
Chapter 2 Demand Filed:    17.12.1997    
IPC:
A61K 9/16 (2006.01), A61K 31/496 (2006.01)
Applicants: SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road, Kenilworth, NJ 07033-0530 (US)
Inventors: SANGEKAR, Surendra, A.; (US).
VADINO, Winston, A.; (US).
LEE, Ping, I.; (US)
Agent: MAJKA, Joseph, T.; Schering-Plough Corporation, Patent Dept. K-6-1 1990, 2000 Galloping Hill Road, Kenilworth, NJ 07033-0530 (US)
Priority Data:
08/672,432 28.06.1996 US
Title (EN) ORAL COMPOSITION COMPRISING A TRIAZOLE ANTIFUNGAL COMPOUND
(FR) COMPOSITION ORALE COMPRENANT UN COMPOSE ANTIFONGIQUE DE TRIAZOLE
Abstract: front page image
(EN)A pharmaceutical composition comprising: i) substantially inert beads; wherein said beads are coated with ii) an antifungal agent which is (-)-(2R-cis)-4-[4-[4-[4-[[-5-(2,4-difluorophenyl)-tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxypropyl]-3H-1,2,4-triazol-3-one; iii) a binder to enable the antifungal compound to adhere to said beads. The composition enables the antifungal compound, which has very low water solubility, to have enhanced bioavailability in mammals, such as humans.
(FR)Composition pharmaceutique comprenant: i) des perles sensiblement inertes qui sont enrobées ii) d'un agent antifongique qui est (-)-(2R-cis)-4-[4-[4-[4-[[-5-(2,4-difluorophényl)-tétrahydro-5-(1H-1,2,4-triazol-1-ylméthyl)furan-3-yl]méthoxy]phényl]-1-pipérazinyl]phényl]-2,4-dihydro-2-[(S)-1-éthyl-2(S)-hydroxypropyl]-3H-1,2,4-triazol-3-one; iii) un liant permettant au composé antifongique d'adhérer auxdites perles. La composition permet au composé antifongique, qui possède une très faible solubilité dans l'eau, d'avoir une meilleure biodisponibilité chez les mammifères tels que les êtres humains.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)