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1. WO1997049395 - SUBSTITUTED 3,5-DIPHENYL-1,2,4-TRIAZOLES AND THEIR USE AS PHARMACEUTICAL METAL CHELATORS

Publication Number WO/1997/049395
Publication Date 31.12.1997
International Application No. PCT/EP1997/003315
International Filing Date 24.06.1997
Chapter 2 Demand Filed 14.11.1997
IPC
C07D 249/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
C07D 401/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
CPC
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 39/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
04Chelating agents
C07D 249/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
C07D 401/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Y10S 514/836
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
514Drug, bio-affecting and body treating compositions
836Chelate
Applicants
  • NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. [AT]/[AT] (AT)
  • NOVARTIS AG [CH]/[CH] (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GN, GR, HU, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
  • LATTMANN, René [CH]/[CH] (UsOnly)
  • ACKLIN, Pierre [CH]/[CH] (UsOnly)
Inventors
  • LATTMANN, René
  • ACKLIN, Pierre
Agents
  • ROTH, Bernhard, M.
Priority Data
1593/9625.06.1996CH
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED 3,5-DIPHENYL-1,2,4-TRIAZOLES AND THEIR USE AS PHARMACEUTICAL METAL CHELATORS
(FR) 3,5-DIPHENYL-1,2,4-TRIAZOLES SUBSTITUES ET LEUR UTILISATION COMME CHELATEURS DE METAUX PHARMACEUTIQUES
Abstract
(EN)
3,5-Diphenyl-1,2,4-triazoles of formula (I) have useful pharmaceutical properties and are particularly active as iron chelators. They can be used for the treatment of an iron overload in the body of warm-blooded animals. Certain of these compounds are novel.
(FR)
L'invention concerne des 3,5-diphényle-1,2,4-triazoles présentant la formule (I). Ces composés présentent des propriétés pharmaceutiques utiles et sont particulièrement actifs comme chélateurs de fer. Ces composés peuvent être utilisés pour traiter les surcharges de fer dans l'organisme d'animaux à sang chaud. Certains de ces composés sont nouveaux.
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