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1. WO1997046881 - METHOD FOR IMPROVING THE PERFORMANCE OF AN IMMUNOREAGENT IN AN IMMUNOASSAY

Publication Number WO/1997/046881
Publication Date 11.12.1997
International Application No. PCT/US1997/009429
International Filing Date 03.06.1997
Chapter 2 Demand Filed 07.01.1998
IPC
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
CPC
G01N 33/54353
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54353with ligand attached to the carrier via a chemical coupling agent
G01N 33/54393
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54393Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
Y10S 435/962
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
435Chemistry: molecular biology and microbiology
962Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
Y10S 435/963
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
435Chemistry: molecular biology and microbiology
963Methods of stopping an enzyme reaction or stabilizing the test materials
Y10S 436/81
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
436Chemistry: analytical and immunological testing
807Apparatus included in process claim, e.g. physical support structures
81Tube, bottle, or dipstick
Y10S 436/823
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
436Chemistry: analytical and immunological testing
823Immunogenic carrier or carrier per se
Applicants
  • ABBOTT LABORATORIES [US]/[US]
Inventors
  • POPE, Mark, R.
  • TARCHA, Peter, J.
  • MEES, David, R.
  • JOSEPH, Mary, K.
  • PRY, Terry, A.
  • PUTMAN, C., Brent
  • SUBOTICH, Daniel, T.
Agents
  • WEINSTEIN, David, L.
Priority Data
08/657,57807.06.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR IMPROVING THE PERFORMANCE OF AN IMMUNOREAGENT IN AN IMMUNOASSAY
(FR) PROCEDE PERMETTANT D'AMELIORER LA PERFORMANCE D'UN REACTIF IMMUNOLOGIQUE DANS UN DOSAGE IMMUNOLOGIQUE
Abstract
(EN)
A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.
(FR)
Procédé permettant d'accroître l'activité de liaison d'éléments de liaison spécifiques liés à une substance en phase solide, telle qu'une particule, qui a été stériquement stabilisée. Cet accroissement de l'activité de liaison résulte de la dégradation d'un stabilisant stérique à la surface de la substance en phase solide. Le procédé implique l'immobilisation d'un élément de liaison spécifique à la surface de la substance en phase solide et la dégradation d'un stabilisant stérique à la surface de ladite substance en phase solide. Dans la forme de réalisation préférée, le procédé consiste à immobiliser un élément de liaison spécifique à la surface de la substance en phase solide stériquement stabilisée, puis à laisser se dégrader le stabilisant stérique.
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