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1. WO1997046661 - A HUMAN RADIORESISTANCE/CELL CYCLE PROGRESSION GENE

Publication Number WO/1997/046661
Publication Date 11.12.1997
International Application No. PCT/US1997/008798
International Filing Date 09.05.1997
Chapter 2 Demand Filed 09.12.1997
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/4738
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4738Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
C12Q 1/6876
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/106
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
Applicants
  • THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US]/[US] (AllExceptUS)
  • QUEEN'S UNIVERSITY AT KINGSTON [CA]/[CA] (AllExceptUS)
  • LIEBERMAN, Howard, B. [US]/[US] (UsOnly)
  • HOPKINS, Kevin, M. [US]/[US] (UsOnly)
  • DAVEY, Scott, K. [CA]/[CA] (UsOnly)
Inventors
  • LIEBERMAN, Howard, B.
  • HOPKINS, Kevin, M.
  • DAVEY, Scott, K.
Agents
  • WHITE, John, P.
Priority Data
08/644,03409.05.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A HUMAN RADIORESISTANCE/CELL CYCLE PROGRESSION GENE
(FR) GENE HUMAIN CONTRE LA PROGRESSION DU CYCLE CELLULAIRE ET LA RADIORESISTANCE
Abstract
(EN)
This invention provides isolated nucleic acids which encode a wildtype and a mutant human homolog of RAD9. This invention also provides purified and mutant wildtype human homologs of RAD9. This invention also provides methods for determining whether a subject has radiosensitivity; for predicting the effect of radiation therapy or chemotherapy on a subject; for detecting whether a subject has a predisposition to cancer; for treating a subject who is radiosensitive and for preventing or treating cancer in a subject who is radiosensitive. This invention further provides a method of detecting cervical carcinoma in a subject.
(FR)
L'invention concerne des acides nucléiques isolés codant un homologue humain et de type sauvage de RAD9, un homologue humain et mutant de RAD9, ainsi que des homologues humains, de type sauvage, mutants et purifiés de RAD9. Elle concerne encore des procédés permettant de déterminer si un sujet présente une radiosensibilité, de prédire les effets d'une thérapie ou chimiothérapie de rayonnement sur un sujet, de détecter si un sujet présente une prédisposition au cancer, de traiter un sujet qui est radiosensible et de prévenir ou traiter le cancer chez un tel sujet. L'invention concerne en outre un procédé de détection d'un cancer du col de l'utérus chez une patiente.
Also published as
Latest bibliographic data on file with the International Bureau