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1. WO1997045415 - POLYAMIDE DERIVATIVES OR ORNITHINE, LYSINE AND ANALOGOUS SUBSTANCES WITH CCK-B AND GASTRIN-ANTAGONISTIC ACTIVITY

Publication Number WO/1997/045415
Publication Date 04.12.1997
International Application No. PCT/EP1996/002288
International Filing Date 28.05.1996
Chapter 2 Demand Filed 19.12.1997
IPC
C07D 221/20 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
221Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/-C07D219/187
02condensed with carbocyclic rings or ring systems
20Spiro-condensed ring systems
C07D 491/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
CPC
C07D 221/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
221Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
02condensed with carbocyclic rings or ring systems
20Spiro-condensed ring systems
C07D 491/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
Applicants
  • ROTTA RESEARCH LABORATORIUM S.P.A. [IT]/[IT] (AllExceptUS)
  • MAKOVEC, Francesco [IT]/[IT] (UsOnly)
  • PERIS, Walter [IT]/[IT] (UsOnly)
  • ROVATI, Lucio, Claudio [IT]/[IT] (UsOnly)
  • ROVATI, Luigi, Angelo [IT]/[IT] (UsOnly)
Inventors
  • MAKOVEC, Francesco
  • PERIS, Walter
  • ROVATI, Lucio, Claudio
  • ROVATI, Luigi, Angelo
Agents
  • RAMBELLI, Paolo
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYAMIDE DERIVATIVES OR ORNITHINE, LYSINE AND ANALOGOUS SUBSTANCES WITH CCK-B AND GASTRIN-ANTAGONISTIC ACTIVITY
(FR) DERIVES POLYAMIDES D'ORNITHINE, DE LYSINE ET DE SUBSTANCES ANALOGUES AYANT UNE ACTIVITE ANTAGONISTE CONTRE LA GASTRINE ET LA CCK-B
Abstract
(EN)
Compounds are described which may be represented by general formula (I) in which: R1 is a simple phenyl group or a phenyl grup mono- or di- substituted with chlorine; R2 is H or CH3; R3 is a heterocyclic spiro ring group represented by (a) in which Y is selected independently from CH2 and O (oxygen) and n is 0 (zero) or 1; s is a whole number from 1 to 4; m, r and t are whole numbers selected independently and ranging from 0 (zero) to 2; z is 0 (zero) or 1; R4 is selected independently from a simple phenyl group and a phenyl group mono- or di- substituted with methyl or chlorine, a 1-(or 2-)napththyl group, a 2-(or 3-)indolyl group, a 2-(or 3-)quinolinyl group. The configuration of the chiral centre indicated * in general formula (I) may be independently D or racemic while that of the chiral centre indicated ** may be independently D, racemic or L.
(FR)
On décrit des composés pouvant être représentés par la formule (I) dans laquelle R1 représente un groupe phényle simple ou un groupe phényle monosubstitué ou bisubstitué par du chlore; R2 représente H ou CH3; R3 représente un groupe à anneau spiro hétérocyclique représenté par la formule (a) dans laquelle Y est sélectionné indépendamment entre CH2 et O (oxygène) et n vaut 0 (zéro) ou 1; s représente une nombre entier compris entre 1 et 4; m, r et t représentent des nombres entiers sélectionnés indépendamment et compris entre 0 (zéro) et 2; z vaut 0 (zéro) ou 1; R4 est sélectionné indépendamment entre un groupe phényle simple et un groupe phényle monosubstitué ou bisubstitué par du méthyle ou du chlore, un groupe 1- (ou 2-) naphthyle, un groupe 2- (ou 3-) indolyle, un groupe 2- (ou 3-) quinolinyle. La configuration du centre chiral indiqué par '*' dans la formule (I) peut être indépendamment D ou racémique alors que celle du centre chiral indiqué par '**' peut être indépendamment D, racémique ou L.
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