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1. (WO1997043300) ADENOSINE DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/043300 International Application No.: PCT/EP1997/002403
Publication Date: 20.11.1997 International Filing Date: 13.05.1997
Chapter 2 Demand Filed: 27.10.1997
IPC:
C07H 15/04 (2006.01) ,C07H 19/16 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02
Acyclic radicals, not substituted by cyclic structures
04
attached to an oxygen atom of a saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
Applicants:
GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
ELLIS, Frank [GB/GB]; GB (UsOnly)
SWANSON, Stephen [GB/GB]; GB (UsOnly)
COUSINS, Richard, Peter, Charles [GB/GB]; GB (UsOnly)
COX, Brian [GB/GB]; GB (UsOnly)
PENNELL, Andrew, Michael, Kenneth [GB/GB]; GB (UsOnly)
ELDRED, Colin, David [GB/GB]; GB (UsOnly)
Inventors:
ELLIS, Frank; GB
SWANSON, Stephen; GB
COUSINS, Richard, Peter, Charles; GB
COX, Brian; GB
PENNELL, Andrew, Michael, Kenneth; GB
ELDRED, Colin, David; GB
Agent:
LEAROYD, Stephanie, Anne; Glaxo Wellcome plc Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB
Priority Data:
9610031.814.05.1996GB
Title (EN) ADENOSINE DERIVATIVES
(FR) DERIVES D'ADENOSINE
Abstract:
(EN) A compound of formula (I) wherein R1 represents phenyl optionally substituted by one or more substituents selected from halogen, C1-3alkyl, trifluoromethyl, nitro, cyano, -CO2Ra, -CONRaRb, -CORa, -SORc, -SO2Rc, -SO3H, -SO2NRaRb, -ORa, -NHSO2Rc, -NHCORa and -NRaRb; R2 represents a C1-6alkyl or C3-6alkenyl group; R3 represents C1-3alkyl; Ra and Rb may each independently represent hydrogen or C1-3alkyl or, when -NRaRb is directly attached to said phenyl, Ra and Rb together with the nitrogen atom may form a 5- or 6- membered heterocyclic ring optionally containing a second heteroatom selected from oxygen or nitrogen, which second nitrogen heteroatom may optionally be further substituted by hydrogen or C1-3alkyl; Rc represents C1-3alkyl; and salts and solvates thereof.
(FR) L'invention concerne un composé de formule (I) dans laquelle R1 représente phényle éventuellement substitué par un ou plusieurs substituants choisis parmi halogène, alkyle C1-3, trifluorométhyle, nitro, cyano, -CO2Ra, -CONRaRb, -CORa, -SORc, -SO2Rc, SO3H, -SO2NRaRb, -ORa, -NHSO2Rc, -NHCORa et -NRaRb; R2 représente un groupe alkyle C1-6 ou alcényle C3-6; R3 représente alkyle C1-3; Ra et Rb peuvent être indépendamment hydrogène ou alkyle C1-3 ou lorsque -NRaRb est directement attaché audit phényle, Ra et Rb conjointement avec l'atome d'azote peuvent former un noyau hétérocyclique à 5 ou 6 éléments contenant éventuellement un second hétéroatome choisi parmi oxygène ou azote, le second hétéroatome d'azote pouvant être éventuellement encore substitué par hydrogène ou alkyle C1-3. L'invention porte également sur des sels et des solvates dudit composé.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU
African Regional Intellectual Property Organization (ARIPO) (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
ES2175405EP0901499US5998388JP2001503382 DE000069711868AU1997028961