Processing

Please wait...

Settings

Settings

Goto Application

1. WO1997040033 - INHIBITION OF THE BINDING OF HUMAN IGE TO ITS RECEPTOR BY TETRACYCLIC COMPOUNDS FOR THE ALLEVIATION OF IGE-MEDIATED IMMUNE RESPONSE

Publication Number WO/1997/040033
Publication Date 30.10.1997
International Application No. PCT/US1997/006636
International Filing Date 18.04.1997
Chapter 2 Demand Filed 14.11.1997
IPC
A61K 31/352 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/4433 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4433containing a six-membered ring with oxygen as a ring hetero atom
C07D 311/82 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
80Dibenzopyrans; Hydrogenated dibenzopyrans
82Xanthenes
CPC
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/4433
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4433containing a six-membered ring with oxygen as a ring hetero atom
C07D 311/82
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
80Dibenzopyrans; Hydrogenated dibenzopyrans
82Xanthenes
Applicants
  • LEXIGEN PHARMACEUTICALS CORP. [US]/[US]
Inventors
  • CHENG, Y.-S., Edmond
  • LIU, Yuan
  • CHU, John
  • KINET, Jean-Pierre
  • JOUVIN, Marie-Helene
  • SUDO, Yukio
  • QIAN, Xiuqi
Agents
  • HANLEY, Elizabeth, A.
Priority Data
08/635,37219.04.1996US
08/698,24315.08.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITION OF THE BINDING OF HUMAN IGE TO ITS RECEPTOR BY TETRACYCLIC COMPOUNDS FOR THE ALLEVIATION OF IGE-MEDIATED IMMUNE RESPONSE
(FR) INHIBITION DE LA LIAISON DE L'IGE HUMAINE A SON RECEPTEUR PAR DES COMPOSES TETRACYCLIQUES POUR L'ATTENUATION DE LA REACTION IMMUNITAIRE INDUITE PAR IGE
Abstract
(EN)
Disclosed are chemical agents with unexpected activity to inhibit the interactions between human immunoglobulin E (IgE) and its receptor (Fc$g(e)RI) which interactions are known to be involved in triggering allergic responses. The agents may be used to modulate the allergic response in the treatment of various clinical conditions, including rhinitis, asthma, urticaria, atopic dermatitis, and anaphylactic shock. The agents can be formulated for oral, topical or parenteral administration.
(FR)
Agents chimiques présentant une activité inattendue en ce qui concerne l'inhibition des interactions entre l'immunoglobuline E humaine (IgE) et son récepteur (Fc$g(e)RI), dont on sait qu'elles sont impliquées dans le déclenchement des réactions allergiques. Ces agents peuvent être utilisés pour moduler la réaction allergique dans le traitement de divers états cliniques, dont la rhinite, l'asthme, l'urticaire, l'eczéma constitutionnel et le choc anaphylactique. Ils peuvent être formulés de façon à être administrés par voie orale, topique ou parentérale.
Also published as
Latest bibliographic data on file with the International Bureau