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Machine translation
1. (WO1997040031) THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/040031    International Application No.:    PCT/US1997/005428
Publication Date: 30.10.1997 International Filing Date: 10.04.1997
Chapter 2 Demand Filed:    23.10.1997    
IPC:
C07D 285/135 (2006.01), C07D 417/12 (2006.01), C07F 7/18 (2006.01)
Applicants: PHARMACIA & UPJOHN COMPANY [US/US]; 301 Henrietta Street, Kalamazoo, MI 49001 (US) (For All Designated States Except US).
JACOBSEN, E., Jon [US/US]; (US) (For US Only).
MITCHELL, Mark, A. [US/US]; (US) (For US Only).
SCHOSTAREZ, Heinrich, Joseph [US/US]; (US) (For US Only).
HARPER, Donald, E. [US/US]; (US) (For US Only)
Inventors: JACOBSEN, E., Jon; (US).
MITCHELL, Mark, A.; (US).
SCHOSTAREZ, Heinrich, Joseph; (US).
HARPER, Donald, E.; (US)
Agent: YANG, Lucy, X.; Pharmacia & Upjohn Company, Intellectual Property Legal Services, 301 Henrietta Street, Kalamazoo, MI 49001 (US).
PERRY, Robert, Edward; Gill Jennings & Every, Broadgate House, 7 Eldon Street, London EC2M 7LH (GB)
Priority Data:
60/016,003 23.04.1996 US
Title (EN) THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS
(FR) THIADIAZOLYL(THIO)UREES UTILES COMME INHIBITEURS DE METALLOPROTEASES A MATRICE
Abstract: front page image
(EN)The present invention provides novel thiadiazole derivatives represented by formula (I) or pharmaceutical acceptable salts thereof wherein the compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, predominantly stromelysins, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthritis, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis (invasion and growth), periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, and other diseases related to connective tissue degradation.
(FR)Nouveaux dérivés de thiadiazole de formule (I), ou leurs sels pharmaceutiquement acceptables. Les composés décrits inhibent différents enzymes de la famille des métalloprotéinases à matrices, essentiellement les stromélysines, et sont de ce fait utiles dans le traitement des maladies liées à l'activité des métalloendoprotéinases à matrice, telles que l'arthrose, la polyarthrite rhumatoïde, l'arthrite aiguë suppurée, les ostéopénies telles que l'ostéoporose, la métastase des tumeurs (invasion et croissance), la périodontite, la gingivite, l'ulcère de la cornée, l'ulcère dermique, l'ulcère gastrique et d'autres maladies liées à la dégradation du tissu conjonctif.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)