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Machine translation
1. (WO1997040028) UREA DERIVATIVES AS INHIBITORS OF IMPDH ENZYME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/040028    International Application No.:    PCT/US1997/006623
Publication Date: 30.10.1997 International Filing Date: 21.04.1997
Chapter 2 Demand Filed:    24.11.1997    
IPC:
A61K 31/404 (2006.01), A61K 31/42 (2006.01), A61K 31/422 (2006.01), C07C 275/42 (2006.01), C07D 263/32 (2006.01), C07D 413/12 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 130 Waverly Street, Cambridge, MA 02139-4242 (US)
Inventors: ARMISTEAD, David, M.; (US).
BADIA, Michael, C.; (US).
BEMIS, Guy, W.; (US).
BETHIEL, Randy, S.; (US).
FRANK, Catharine, A.; (US).
NOVAK, Perry, M.; (US).
RONKIN, Steven, M.; (US).
SAUNDERS, Jeffrey, O.; (US)
Agent: HALEY, James, F., Jr.; Fish & Neave, 1251 Avenue of the Americas, New York, NY 10020-1104 (US)
Priority Data:
08/636,361 23.04.1996 US
08/801,780 14.02.1997 US
08/832,165 02.04.1997 US
Title (EN) UREA DERIVATIVES AS INHIBITORS OF IMPDH ENZYME
(FR) DERIVES D'UREE AGISSANT COMME INHIBITEURS DE L'ENZYME IMPDH
Abstract: front page image
(EN)The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
(FR)Nouvelle classe de composés agissant comme inhibiteurs de l'inosine-5'-monophosphate déshydrogénase (IMPDH) et compositions pharmaceutiques les contenant. Ces composés et ces compositions pharmaceutiques conviennent particulièrement à l'inhibition de l'activité de l'enzyme dite IMPDH et, en conséquence, peuvent être avantageusement utilisés comme agents thérapeutiques pour traiter des processus induits par IMPDH. L'invention se rapporte également à des méthodes destinées à inhiber l'activité de l'IMPDH au moyen des composés selon cette invention et de composés apparentés.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)