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Machine translation
1. (WO1997039768) A PHARMACEUTICAL FORMULATION CONTAINING GROWTH HORMONE, AN AMINO ACID AND A NON-IONIC DETERGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1997/039768 International Application No.: PCT/DK1997/000184
Publication Date: 30.10.1997 International Filing Date: 24.04.1997
Chapter 2 Demand Filed: 11.11.1997
IPC:
A61K 9/08 (2006.01) ,A61K 38/27 (2006.01) ,A61K 47/10 (2006.01) ,A61K 47/18 (2006.01) ,A61K 47/26 (2006.01)
Applicants: BJØRN, Søren[DK/DK]; DK (UsOnly)
SØRENSEN, Hans, Holmegaard[DK/DK]; DK (UsOnly)
LANGBALLE, Peter[DK/DK]; DK (UsOnly)
LARSEN, Silke, Møller[DK/DK]; DK (UsOnly)
EBBEHØJ, Kirsten[DK/DK]; DK (UsOnly)
HANSEN, Birthe, Lykkegaard[DK/DK]; DK (UsOnly)
NOVO NORDISK A/S[DK/DK]; Novo Allé DK-2880 Bagsværd, DK (AllExceptUS)
Inventors: BJØRN, Søren; DK
SØRENSEN, Hans, Holmegaard; DK
LANGBALLE, Peter; DK
LARSEN, Silke, Møller; DK
EBBEHØJ, Kirsten; DK
HANSEN, Birthe, Lykkegaard; DK
Common
Representative:
NOVO NORDISK A/S; Corporate Patents Novo Allé DK-2880 Bagsvaerd, DK
Priority Data:
0490/9624.04.1996DK
Title (EN) A PHARMACEUTICAL FORMULATION CONTAINING GROWTH HORMONE, AN AMINO ACID AND A NON-IONIC DETERGENT
(FR) FORMULATION PHARMACEUTIQUE CONTENANT UNE HORMONE DE CROISSANCE, UN ACIDE AMINE ET UN DETERGENT NON IONIQUE
Abstract:
(EN) The invention relates to pharmaceutical formulations comprising growth hormone, an amino acid selected from the group of Asp, Ile, Val, Leu or His, or a derivative of histidine, or a peptide comprising at least one basic amino acid and at least one acidic amino acid, and a non-ionic detergent, e.g. polysorbate or poloxamer. The formulation is stabilized against deamidation and aggregation. The formulation may be an aqueous formulation. The growth hormone may be human growth hormone.
(FR) Cette invention concerne des formulations pharmaceutiques qui contiennent une hormone de croissance. Ces formulations contiennent également un acide aminé choisi dans le groupe Asp, Ile, Val, Leu et His, ou un dérivé d'histidine ou, encore, un peptide comprenant un ou plusieurs acides aminés basiques et un ou plusieurs acides aminés acides. Ces formulations comprennent enfin un détergent non ionique comme, par exemple, un polysorbate ou un poloxamère. Ces formulations restent stables en ce qui concerne la déamidation et l'agrégation, et peuvent se présenter sous forme d'une formulation aqueuse, l'hormone de croissance pouvant quant à elle consister en une hormone de croissance humaine.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU
African Regional Intellectual Property Organization (ARIPO) (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)