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Machine translation
1. (WO1997039759) OMEGA-3 FATTY ACIDS AND OMEGA-3 PHOSPHATIDYLCHOLINE IN THE TREATMENT OF BIPOLAR DISORDER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/039759    International Application No.:    PCT/US1997/006712
Publication Date: 30.10.1997 International Filing Date: 23.04.1997
Chapter 2 Demand Filed:    20.10.1997    
IPC:
A61K 31/202 (2006.01), A61K 33/00 (2006.01), C07F 9/10 (2006.01)
Applicants: BRIGHAM AND WOMEN'S HOSPITAL [US/US]; 75 Francis Street, Boston, MA 02115 (US) (For All Designated States Except US).
STOLL, Andrew, L. [US/US]; (US) (For US Only).
SEVERUS, Wolfram, E. [DE/DE]; (DE) (For US Only)
Inventors: STOLL, Andrew, L.; (US).
SEVERUS, Wolfram, E.; (DE)
Agent: SANZO, Michael, A.; Vinson & Elkins, 1455 Pennsylvania Avenue, N.W., Washington, DC 20004 (US).
GILL JENNINGS & EVERY; Broadgate House, 7 Eldon Street, London EC2M 7LH (GB)
Priority Data:
60/016,140 24.04.1996 US
Title (EN) OMEGA-3 FATTY ACIDS AND OMEGA-3 PHOSPHATIDYLCHOLINE IN THE TREATMENT OF BIPOLAR DISORDER
(FR) ACIDES GRAS OMEGA 3 ET PHOSPHATIDYLCHOLINE OMEGA 3 UTILISES DANS LE TRAITEMENT DE TROUBLES BIPOLAIRES
Abstract: front page image
(EN)The present invention is directed to a method of treating patients with bipolar disorder by administering omega-3 fatty acids. These may be administered in a substantially purified form, as part of a pharmaceutical composition, or as part of a larger molecule, e.g. a triacylglycerol, which releases free fatty acid after ingestion by a patient. The present invention is also directed to triacylglycerols which are esterified at the gamma carbon of glycerol to phosphocholine and at either the alpha or beta carbon of glycerol to an omega-3 fatty acid. These 'omega-3 phosphatidylcholines' are also used in the treatment of patients with bipolar disorder.
(FR)L'invention concerne une méthode de traitement de patients souffrant de troubles bipolaires, qui consiste à administrer des acides gras oméga 3. Ces acides peuvent être administrés sous une forme sensiblement purifiée, en tant que partie d'une composition pharmaceutique ou d'une molécule plus grosse tel qu'un triacylglycérol, qui libère l'acide gras libre après avoir été ingéré par le patient. L'invention concerne aussi des triacylglycérols qui sont estérifiés au niveau du carbone gamma du glycérol de sorte que de la phosphocoline soit produite au niveau du carbone alpha ou bêta du glycérol de sorte qu'un acide gras oméga 3 soit produit. Ces phosphatidylcholines sont également utilisées dans le traitement de patients souffrant de troubles bipolaires.
Designated States: AU, CA, JP, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)