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Machine translation
1. (WO1997039143) METHODS FOR THE IDENTIFICATION OF NOVEL ANTIFUNGAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/039143    International Application No.:    PCT/US1997/006304
Publication Date: 23.10.1997 International Filing Date: 17.04.1997
Chapter 2 Demand Filed:    17.11.1997    
IPC:
C12N 9/16 (2006.01), C12Q 1/48 (2006.01)
Applicants: ABBOTT LABORATORIES [US/US]; CHAD 0377/AP6D-2, 100 Abbott Park Road, Abbott Park, IL 60064-3500 (US).
UNIVERSITY TECHNOLOGY CORPORATION [US/US]; Suite 250, 3101 Iris Avenue, Boulder, CO 80301-1900 (US)
Inventors: FOSTEL, Jennifer, Marion; (US).
WINEY, Mark, Edward; (US).
STEINER, Estelle, Marthe; (US).
LUCA, Francis, Conrad; (US)
Agent: DANCKERS, Andreas, M.; Abbott Laboratories, CHAD 0377/AP6D-2, 100 Abbott Park Road, Abbott Park, IL 60064-3500 (US)
Priority Data:
08/633,617 17.04.1996 US
Title (EN) METHODS FOR THE IDENTIFICATION OF NOVEL ANTIFUNGAL AGENTS
(FR) PROCEDE POUR IDENTIFIER DE NOUVEAUX AGENTS ANTIFONGIQUES
Abstract: front page image
(EN)Assay methods for the identification of antifungal agents, comprising the steps of (a) combining an appropriate checkpoint protein kinase with a test compound; (b) catalyzing phosphorylation of a kinase substrate with the combined kinase and test compound under conditions suitable for said phosphorylation; and (c) determining the extent of phosphorylation of the substrate. Also disclosed are polypeptides and fusion proteins useful in such methods, as well as DNA plasmids and transformed host cells useful in the preparation of such polypeptides and fusion proteins.
(FR)L'invention concerne des méthodes de criblage permettant d'identifier des agents antifongiques. Dans lesdites méthodes (a) on combine une protéine kinase de point de contrôle appropriée à un composé test; (b) on catalyse la phosphorylation d'un substrat à base de kinase, la kinase et le composé test étant dans des conditions appropriées pour ladite phosphorylation; et (c) on détermine le degré de phosphorylation du substrat. L'invention concerne également des polypeptides et des protéines de fusion utiles pour lesdites méthodes, ainsi que des ADN plasmidiques et des cellules hôtes transformées utiles pour la préparation desdits polypeptides et protéines de fusion.
Designated States: CA, JP, MX.
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)