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1. (WO1997039024) CYCLIC PRODRUGS OF PEPTIDES AND PEPTIDE NUCLEIC ACIDS HAVING IMPROVED METABOLIC STABILITY AND CELL MEMBRANE PERMEABILITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/039024    International Application No.:    PCT/US1996/004180
Publication Date: 23.10.1997 International Filing Date: 08.04.1996
Chapter 2 Demand Filed:    22.11.1996    
IPC:
A61K 38/00 (2006.01), C07K 1/107 (2006.01), C07K 5/107 (2006.01), C07K 7/06 (2006.01), C07K 14/665 (2006.01), C07K 14/70 (2006.01)
Applicants: THE UNIVERSITY OF KANSAS [US/US]; 222 Strong Hall, Lawrence, KS 66045 (US)
Inventors: BORCHARDT, Donald, T.; (US).
SIAHAAN, Teruna; (US).
GANGWAR, Sanjeev; (US).
STELLA, Valentino, J.; (US).
WANG, Binghe; (US)
Agent: SVENSSON, Leonard, R.; Birch, Stewart, Kolasch & Birch, L.L.P., P.O. Box 747, Falls Church, VA 22040-0747 (US)
Priority Data:
08/429,732 25.04.1995 US
Title (EN) CYCLIC PRODRUGS OF PEPTIDES AND PEPTIDE NUCLEIC ACIDS HAVING IMPROVED METABOLIC STABILITY AND CELL MEMBRANE PERMEABILITY
(FR) BIOPRECURSEURS CYCLIQUES DE PEPTIDES ET ACIDES NUCLEIQUES PEPTIDES FAISANT PREUVE D'UNE MEILLEURE STABILITE METABOLIQUE ET D'UNE MEILLEURE PERMEABILITE DE LA MEMBRANE CELLULAIRE
Abstract: front page image
(EN)Provided are cyclic prodrugs of biologically active peptides and peptide nucleic acids exhibiting improved cell membrane permeability and enzymatic stability, containing 3-(2'-hydroxy-4',6'-dimethyl phenyl)-3,3-dimethyl propionic acid and its derivatives and acyloxyalkoxy linkers. Also provided are pharmaceutical compositions containing effective amounts of these cyclic prodrugs in combination with pharmaceutically acceptable carriers, excipients, or diluents.
(FR)La présente invention concerne des bioprécurseurs cycliques de peptides biologiquement actifs et d'acides nucléiques peptides faisant preuve d'une meilleure perméabilité de la membrane cellulaire. De tel bioprécurseurs, qui contiennent de l'acide propionique de 3-(2'-hydroxy-4',6'-diméthyl phényl)-3,3-diméthyle et ses dérivés, contiennent également des liants de type acyloxyalcoxy. L'invention concerne également des compositions pharmaceutiques contenant des quantités suffisantes de ces bioprécurseurs, combinés avec des vecteurs, des excipients ou des diluants admis en pharmacie.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)