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1. (WO1997038999) ACRIDONE-DERIVED COMPOUNDS USEFUL AS ANTINEOPLASTIC AND ANTIRETROVIRAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/038999    International Application No.:    PCT/US1997/007070
Publication Date: 23.10.1997 International Filing Date: 09.04.1997
Chapter 2 Demand Filed:    15.10.1997    
IPC:
C07D 471/06 (2006.01), C07D 519/00 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer, National Institutes of Health, Suite 325, 6011 Executive Boulevard, Rockville, MD 20852 (US) (For All Designated States Except US).
MICHEJDA, Christopher, J. [US/US]; (US) (For US Only).
CHOLODY, Marek, W. [PL/PL]; (US) (For US Only).
RICE, William, G. [US/US]; (US) (For US Only).
TURPIN, James, A. [US/US]; (US) (For US Only)
Inventors: MICHEJDA, Christopher, J.; (US).
CHOLODY, Marek, W.; (US).
RICE, William, G.; (US).
TURPIN, James, A.; (US)
Agent: FEILER, William, S.; Morgan & Finnegan, L.L.P., 345 Park Avenue, New York, NY 10154 (US)
Priority Data:
60/015,326 12.04.1996 US
60/035,050 22.01.1997 US
Title (EN) ACRIDONE-DERIVED COMPOUNDS USEFUL AS ANTINEOPLASTIC AND ANTIRETROVIRAL AGENTS
(FR) COMPOSES DERIVES DE L'ACRIDONE UTILES EN TANT QU'AGENTS ANTINEOPLASIQUES ET ANTIRETROVIRAUX
Abstract: front page image
(EN)The present invention relates to several novel acridone-derived compounds of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as Human Immunodeficiency Virus. In addition, these compounds are anti-neoplastic agents useful in the treatment of various forms of cancer. In said formula (I) or (II) R¿1? and R¿2? are independently -H, -OH, amino, alkylamino, dialkylamino, alkoxy, alkyl, haloalkyl or halogen; n is 2 to 6, X and X' are independently -N or -NO¿2?; Y and Y' are independently -N or -CH, or -H; and the double-slash represents a double bond or no bond.
(FR)La présente invention concerne plusieurs nouveaux composés dérivés de l'acridone, de formule (I) ou (II), qui sont de puissants agents antiviraux, utiles dans le traitement de maladies virales, telles que celle due au virus de l'immunodéficience humaine. De plus, ces composés sont des agents antinéoplasiques utiles dans le traitement de diverses formes de cancer. Dans lesdites formules, R¿1? et R¿2? sont indépendamment -H, -OH, amino, alkylamino, dialkylamino, alcoxy, alkyle, haloalkyle ou halogène; n est 2 à 6; X et X' sont indépendamment -N ou -NO¿2?; Y et Y' sont indépendamment -N ou -CH, ou -H; et la double barre oblique représente une double liaison ou pas de liaison du tout.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)