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1. (WO1997038990) NOVEL N-AMINOALKYL-1-BIPHENYLENYL-2-CARBOXAMIDES; NEW DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/038990    International Application No.:    PCT/US1997/006210
Publication Date: 23.10.1997 International Filing Date: 14.04.1997
Chapter 2 Demand Filed:    10.11.1997    
IPC:
C07D 217/22 (2006.01), C07D 295/13 (2006.01)
Applicants: NEUROGEN CORPORATION [US/US]; 35 Northeast Industrial Road, Branford, CT 06405 (US) (For All Designated States Except US).
CHEN, Xi [US/US]; (US) (For US Only).
YUAN, Jun [US/US]; (US) (For US Only)
Inventors: CHEN, Xi; (US).
YUAN, Jun; (US)
Agent: SARUSSI, Steven, J.; McDonnell Boehnen Hulbert & Berghoff, 300 South Wacker Drive, Chicago, IL 60606 (US)
Priority Data:
08/631,152 15.04.1996 US
Title (EN) NOVEL N-AMINOALKYL-1-BIPHENYLENYL-2-CARBOXAMIDES; NEW DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS
(FR) NOUVEAUX N-AMINOALKYL-1-BIPHENYLENYL-2-CARBOXAMIDES; NOUVEAUX LIGANDS SPECIFIQUES DE SOUS-TYPES DE RECEPTEURS DE LA DOPAMINE
Abstract: front page image
(EN)Disclosed are compounds of formula (I) or the pharmaceutically acceptable acid addition salts thereof wherein: R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6? and R¿7? independently represent hydrogen, halogen, hydroxy, alkyl, alkoxy, amino, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, cyano, nitro, trifluoromethyl, or trifluoromethoxy; R¿8? is hydrogen or lower alkyl; X represents an optionally substituted alkylene group; and Y represents a mono-, di- or trisubstituted cyclic amino group, which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which responds to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.
(FR)L'invention se rapporte à des composés représentés par la formule (I) ou à des sels d'addition d'acide pharmaceutiquement acceptables de ces composés. Dans la formule (I), R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6? et R¿7? sont indépendamment hydrogène, halogène, hydroxy, alkyle, alcoxy, amino, aminosulfonyle, alkylaminosulfonyle, dialkylaminosulfonyle, cyano, nitro, trifluorométhyle ou trifluorométhoxy, R¿8? est hydrogène ou alkyle inférieur; X représente un groupe alkylène éventuellement substitué et Y représente un groupe amino cyclique mono-, di- ou trisubstitué. Ces composés peuvent servir au traitement des troubles affectifs du type schizophrénie, dépression, maladie d'Alzheimer, troubles de la fonction motrice tels que le Parkinsonisme et la dystonie, et d'autres troubles qui réagissent à un blocage dopaminergique du type abus d'intoxicants et névroses obsessionnelles. En outre, les composés de cette invention peuvent s'avérer utiles s'agissant de traiter les effets secondaires extrapyramidaux liés à l'utilisation des neuroleptiques classiques.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)