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1. WO1997038976 - METHOD OF PREPARING PHOSPHODIESTERASE IV INHIBITORS

Publication Number WO/1997/038976
Publication Date 23.10.1997
International Application No. PCT/US1997/006131
International Filing Date 14.04.1997
Chapter 2 Demand Filed 12.11.1997
IPC
C07D 213/34 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
28Radicals substituted by singly-bound oxygen or sulfur atoms
32Sulfur atoms
34to which a second hetero atom is attached
CPC
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
C07D 213/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
28Radicals substituted by singly-bound oxygen or sulfur atoms
32Sulfur atoms
34to which a second heteroatom is attached
Applicants
  • MERCK & CO., INC. [US]/[US] (AllExceptUS)
  • HOUPIS, Ioannis [GR]/[US] (UsOnly)
  • MOLINA, Audrey [US]/[US] (UsOnly)
  • VOLANTE, Ralph, P. [US]/[US] (UsOnly)
Inventors
  • HOUPIS, Ioannis
  • MOLINA, Audrey
  • VOLANTE, Ralph, P.
Common Representative
  • MERCK & CO., INC.
Priority Data
60/015,68717.04.1996US
9612083.710.06.1996GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF PREPARING PHOSPHODIESTERASE IV INHIBITORS
(FR) PROCEDE DE PREPARATION D'INHIBITEURS DE PHOSPHODIESTERASE IV
Abstract
(EN)
A process for the preparation of a compound of structural formula (1) wherein R1 is alkyl, alkenyl, phenyl or substituted phenyl, which comprises the addition of R1 to an intermediate (2): b y treatment of (2) with (R1)3M followed by reductive removal of the sulfinyl group.
(FR)
La présente invention a pour objet un procédé de préparation d'un composé de la formule structurelle (1) dans laquelle R1 représente alkyle, alcényle, phényle ou phényle substitué, ledit procédé comprenant l'adjonction de R1 à un produit intermédiaire (2) par traitement de 2 avec (R1)3M suivi d'une élimination réductrice du groupe sulfinyle.
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