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1. WO1997038735 - METHOD OF PREVENTING SKIN IRRITATION CAUSED BY FECAL ENZYMES

Publication Number WO/1997/038735
Publication Date 23.10.1997
International Application No. PCT/US1997/005848
International Filing Date 10.04.1997
Chapter 2 Demand Filed 14.10.1997
IPC
A61F 13/15 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
13Bandages or dressings; Absorbent pads
15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
A61L 15/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
15Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
18containing inorganic materials
CPC
A61F 13/8405
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
13Bandages or dressings
15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body
84Accessories, not otherwise provided for, for absorbent pads
8405Additives, e.g. for odour, disinfectant or pH control
A61L 15/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
15Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
18containing inorganic materials
Applicants
  • ENVIRODERM PHARMACEUTICALS, INC. [US]/[US]
Inventors
  • SCHULZ, Anthony, A.
Agents
  • BOLAND, Thomas, R.
Priority Data
08/631,11912.04.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF PREVENTING SKIN IRRITATION CAUSED BY FECAL ENZYMES
(FR) PREVENTION DE L'IRRITATION DE LA PEAU PAR DES ENZYMES FECALES
Abstract
(EN)
Skin irritation, such as diaper rash, appearing when the skin is allowed to remain in contact with proteolytic enzymes found in feces is prevented by inactivating the fecal proteolytic enzymes by contact with organophilic clays. The organophilic clays are applied to the skin in areas likely to come into contact with feces or to garments such as diapers. A composition suitable for practicing the method of the invention comprises an amount of an organophilic clay effective to inactivate irritating fecal proteolytic enzymes dispersed in a pharmaceutically acceptable non-toxic dermatological vehicle. A fabric incorporating organophilic clay, preferably dispersed in a matrix of a superabsorbent polymer, is useful for preparing diapers for infants that can help to prevent skin irritation by fecal enzymes.
(FR)
La présente invention concerne la prévention de l'irritation de la peau telle que l'érythème fessier du nourrisson qui se produit lorsque la peau doit rester en contact avec les enzymes protéolytiques des matières fécales. Le procédé consiste à inactiver ces enzymes protéolytiques par une mise en contact avec des argiles organophiliques. On applique ces argiles organophiliques sur des zones de la peau susceptibles d'entrer en contact avec les matières fécales ou sur des vêtements tels que des couches de bébés. L'invention concerne également une composition convenant particulièrement à la mise en oeuvre du procédé de l'invention. Cette composition, qui renferme une quantité d'une argile organophilique suffisante pour inactiver les enzymes protéolytiques, est dispersée dans un excipient dermatologique non toxique admis en pharmacie. L'invention concerne enfin un produit textile incorporant de l'argile organophilique dispersée de préférence dans une matrice d'un polymère superabsorbant, ce qui fait que ce produit textile convient particulièrement à la confection de couches pour bébés susceptibles de prévenir l'irritation de la peau par des enzymes fécales.
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