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Pub. No.:    WO/1997/038706    International Application No.:    PCT/US1997/005735
Publication Date: 23.10.1997 International Filing Date: 07.04.1997
Chapter 2 Demand Filed:    27.10.1997    
A61K 38/00 (2006.01), C07K 9/00 (2006.01)
Applicants: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center, Indianapolis, IN 46285 (US) (For All Designated States Except US).
STACK, Douglas, R. [US/US]; (US) (For US Only).
THOMPSON, Richard, C. [US/US]; (US) (For US Only)
Inventors: STACK, Douglas, R.; (US).
THOMPSON, Richard, C.; (US)
Agent: PAGE, Kathleen, R., S.; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 (US)
Priority Data:
60/015,300 12.04.1996 US
60/031,735 25.11.1996 US
Abstract: front page image
(EN)The present invention is directed to certain glycopeptide dimers in which two glycopeptide units are covalently linked to one another through their disaccharide amine, via a linking radical. This invention is also directed to the monomeric intermediates. All of these compounds are useful as antibacterials, especially for the control of gram positive bacteria; the compounds are particularly useful for the control of resistant bacterial strains, such as vancomycin-resistant-enterococci ('VRE').
(FR)La présente invention concerne certains dimères glycopeptidiques dans lesquels les deux unités glycopeptidiques sont liées l'une à l'autre par covalence au moyen de leur disaccharide amine via un radical de liaison. L'invention concerne également des intermédiaires monomères. Tous ces composés conviennent comme agents antibactériens, et particulièrement pour combattre une bactérie Gram positive; de tels composés conviennent particulièrement pour combattre les souches bactériennes résistantes telles que les entérocoques résistants à la vancomycine ou 'VRE' $i((Vancomycin-Resistant-Enterococci)).
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, RO, RU, SD, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)