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1. WO1997038109 - IMMUNOLOGICAL REJECTION OF TRANSFECTED TUMOUR CELLS

Publication Number WO/1997/038109
Publication Date 16.10.1997
International Application No. PCT/AU1997/000214
International Filing Date 03.04.1997
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 9/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 9/1051
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
10Transferases (2.)
1048Glycosyltransferases (2.4)
1051Hexosyltransferases (2.4.1)
Applicants
  • ST. VINCENT INSTITUTE OF MEDICAL RESEARCH [AU]/[AU] (AllExceptUS)
  • ST. VINCENT'S HOSPITAL [AU]/[AU] (AllExceptUS)
  • POWER, David, Anthony [AU]/[AU] (UsOnly)
  • KEMP, Bruce, Ernest [AU]/[AU] (UsOnly)
Inventors
  • POWER, David, Anthony
  • KEMP, Bruce, Ernest
Agents
  • F.B. RICE & CO.
Priority Data
PN 912303.04.1996AU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMMUNOLOGICAL REJECTION OF TRANSFECTED TUMOUR CELLS
(FR) REJET IMMUNOLOGIQUE DE CELLULES TUMORALES TRANSFECTEES
Abstract
(EN)
The present invention provides a method of inducing an immune response against human tumour cells which can be used in the treatment of tumours in humans. The method involves transfecting the tumour cells with a polynucleotide encoding a glycosyltransferase. The glycosyltransferase may be selected from $g(a)-1,3 galactosyltransferase, $g(a)-N-acetyl-D-galactosaminyltransferase and $g(a)-D-galactosyltransferase.
(FR)
La présente invention concerne un procédé d'induction d'une réponse immune dirigée contre des cellules tumorales humaines, lequel peut être utile dans le traitement de tumeurs chez l'homme. Ce procédé consiste à transfecter les cellules tumorales à l'aide d'un polynucléotide codant une glycosyltransférase, laquelle peut être choisie parmi une $g(a)-1,3 galactosyltransférase, une $g(a)-N-acétyl-D-galactosaminyltransférase et une $g(a)-D-galactosyltransférase.
Also published as
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