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1. (WO1997037995) CALIXPYRROLES, CALIXPYRIDINOPYRROLES AND CALIXPYRIDINES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/037995    International Application No.:    PCT/US1997/005643
Publication Date: 16.10.1997 International Filing Date: 04.04.1997
Chapter 2 Demand Filed:    17.10.1997    
IPC:
B01J 45/00 (2006.01), C07D 471/22 (2006.01), C07D 487/22 (2006.01), C07D 495/22 (2006.01), C07D 498/22 (2006.01), C07D 519/00 (2006.01), C07F 17/02 (2006.01), G01N 30/02 (2006.01), G01N 30/88 (2006.01), G21F 9/06 (2006.01), G21F 9/12 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street, Austin, TX 78701 (US)
Inventors: GALE, Philip, A.; (US).
SESSLER, Jonathan, L.; (US).
GENGE, John, W.; (US).
KRÁL, Vladimir; (CZ).
ANDRIEVSKY, Andrei; (US).
LYNCH, Vincent; (US).
SANSOM, Petra, I.; (US).
ALLEN, William, E.; (US).
BROWN, Christopher, T.; (US).
GEBAUER, Andreas; (US)
Agent: NORBERG, Gloria, L.; Akin, Gump, Strauss, Hauer & Feld, L.L.P., 1900 Frost Bank Plaza, 816 Congress Avenue, Austin, TX 78701 (US)
Priority Data:
60/014,890 05.04.1996 US
60/024,203 27.08.1996 US
60/026,694 25.09.1996 US
60/033,395 17.12.1996 US
60/033,396 17.12.1996 US
Title (EN) CALIXPYRROLES, CALIXPYRIDINOPYRROLES AND CALIXPYRIDINES
(FR) CALIXPYRROLES, CALIXPYRIDINOPYRROLES ET CALIXPYRIDINES
Abstract: front page image
(EN)The present invention provides calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles, having 4, 5, 6, 7, or 8 heterocyclic rings, as well as syntheses, derivatives, conjugates, multimers, and solid supports thereof. Such macrocycles have proved to be effective and selective ion- and neutral molecule-binding agents forming supramolecular ensembles, and ion- and neutral molecule-separation agents. The macrocycles are fully $i(meso)-non-hydrogen-substituted porphyrinogens, a few molecules of which were previously known but not recognized as possessing anion- or molecule-binding properties. The binding mode is noncovalent, primarily that of hydrogen-bonding, thereby providing a new mode for liquid chromatography, that of Hydrogen Bonding Liquid Chromatography. Further useful applications of the macrocycles provided herein include environmental remediation by removal of undesired ions or neutral molecules, and removal of phosphate for kidney dialysis.
(FR)L'invention concerne des macrocycles calixpyrroles, calixpyridinopyrroles et calixpyridines, possédant 4, 5, 6, 7 ou 8 noyaux hétérocycliques, ainsi que leurs synthèses, dérivés, conjugués, multimères et supports solides. Ces macrocycles se sont avérés être des agents de liaison des ions et des molécules neutres efficaces et sélectifs, formant des ensembles supramoléculaires, ainsi que des agents de séparation des ions et des molécules neutres. Ils constituent des porphyrinogènes totalement $i(méso), sans substituant hydrogène dont certaines molécules étaient déjà connues, mais pas les propriétés de liaison anionique ou moléculaire de celles-ci. Le mode de liaison, non covalent, est à l'origine une liaison hydrogène, ce qui donne un nouveau procédé de chromatographie en phase liquide, la chromatographie en phase liquide par liaison hydrogène. Parmi les autres applications utiles des macrocycles cités ici, on trouve le traitement de l'environnement par élimination des ions ou des molécules neutres indésirables, et l'élimination des phosphates en dialyse rénale.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)