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1. (WO1997037980) PROCESS TO PREPARE OXAZOLIDINONES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1997/037980 International Application No.: PCT/US1997/003458
Publication Date: 16.10.1997 International Filing Date: 28.03.1997
Chapter 2 Demand Filed: 23.10.1997
IPC:
C07D 263/20 (2006.01) ,C07D 263/24 (2006.01) ,C07D 413/10 (2006.01) ,C07D 487/04 (2006.01) ,C07D 521/00 (2006.01)
Applicants: PEARLMAN, Bruce, A.[US/US]; US (UsOnly)
PERRAULT, William, R.[US/US]; US (UsOnly)
BARBACHYN, Michael, R.[US/US]; US (UsOnly)
MANNINEN, Peter, R.[US/US]; US (UsOnly)
TOOPS, Dana, S.[US/US]; US (UsOnly)
HOUSER, David, J.[US/US]; US (UsOnly)
FLECK, Thomas, J.[US/US]; US (UsOnly)
PHARMACIA & UPJOHN COMPANY[US/US]; 301 Henrietta Street Kalamazoo, MI 49001, US (AllExceptUS)
Inventors: PEARLMAN, Bruce, A.; US
PERRAULT, William, R.; US
BARBACHYN, Michael, R.; US
MANNINEN, Peter, R.; US
TOOPS, Dana, S.; US
HOUSER, David, J.; US
FLECK, Thomas, J.; US
Agent: STEIN, Bruce; Pharmacia & Upjohn Company Intellectual Property Legal Services 301 Henrietta Street Kalamazoo, MI 49001, US
PERRY, Robert, Edward; Gill Jennings & Every Broadgate House 7 Eldon Street London EC2M 7LM, GB
Priority Data:
60/015,49911.04.1996US
Title (EN) PROCESS TO PREPARE OXAZOLIDINONES
(FR) PROCEDE DE PREPARATION D'OXAZOLIDINONES
Abstract:
(EN) The present invention includes processes for producing 5-hydroxymethyl substituted oxazolidinone alcohols (III) from carbamates (IIA) or a trifluoroacetamide (IIB) using a dihydroxy compound (I) or glycidol (IV) starting material and for the transformation of the hydroxymethyl substituted oxazolidinone alcohols (III) to the corresponding amino compounds, 5-aminomethyl substituted oxazolidinone amines (VII) which are acylated to form commercially useful antibacterial 5-acylamidomethyl substituted oxazolidinone (VIII).
(FR) La présente invention a pour objet des procédés de fabrication d'alcools d'oxazolidinone (III), à substitution 5-hydroxyméthyle à partir de carbamates (IIA) ou d'un trifluoroacétamide (IIB), dans lequel on utilise comme produit de départ un composé dihydroxy (I) ou un glycidol (IV), et de transformation des alcools d'oxazolidinone (III) à substitution hydroxyméthyle en composés aminés correspondants et en amines d'oxazolidinone (VII) à substitution 5- hydroxymethyle qui sont acylées pour former un oxazolidinone (VIII) à substitution 5-hydroxyméthyle utile, commercialement parlant, en tant qu'anti-bactérien.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU
African Regional Intellectual Property Organization (ARIPO) (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)