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1. (WO1997037677) A SYNTHETIC PEPTIDE AND ITS USES

Pub. No.:    WO/1997/037677    International Application No.:    PCT/US1997/005638
Publication Date: Oct 16, 1997 International Filing Date: Apr 4, 1997
IPC: A61K 38/00
A61K 38/16
A61K 38/17
C07K 14/31
C07K 14/47
Applicants: ANDERSON, Byron, E.
BAUMANN, Michael, A.
FRYER, Jonathan, P.
Inventors: ANDERSON, Byron, E.
BAUMANN, Michael, A.
FRYER, Jonathan, P.
Title: A SYNTHETIC PEPTIDE AND ITS USES
Abstract:
The invention provides a fragment of C1q which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence [SEQ ID NO 2]: Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala Thr or variants thereof capable of binding immunoglobulin. Like the C1q fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides methods of treating an inflammatory response and prolonging the survival of transplanted tissue.