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1. (WO1997037228) METHODS FOR DIAGNOSING AND TREATING ALZHEIMER'S DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/037228    International Application No.:    PCT/US1997/004966
Publication Date: 09.10.1997 International Filing Date: 28.03.1997
Chapter 2 Demand Filed:    06.10.1997    
IPC:
A61K 38/00 (2006.01), C07K 5/09 (2006.01), C07K 14/47 (2006.01), C07K 14/48 (2006.01), G01N 33/68 (2006.01)
Applicants: THE TRUSTEES OF BOSTON UNIVERSITY [US/US]; 147 Bay State Road, Boston, MA 02215 (US) (For All Designated States Except US).
GILCHREST, Barbara, A. [US/US]; (US) (For US Only).
YAAR, Mina [US/US]; (US) (For US Only)
Inventors: GILCHREST, Barbara, A.; (US).
YAAR, Mina; (US)
Agent: GRANAHAN, Patricia; Hamilton, Brook, Smith & Reynolds, P.C., Two Militia Drive, Lexington, MA 02173 (US)
Priority Data:
08/625,765 29.03.1996 US
Title (EN) METHODS FOR DIAGNOSING AND TREATING ALZHEIMER'S DISEASE
(FR) PROCEDES POUR DIAGNOSTIQUER ET TRAITER LA MALADIE D'ALZHEIMER
Abstract: front page image
(EN)Methods for evaluating the risk of an individual to develop Alzheimer's disease using cultured neural crest-derived melanocytes are described. Also described are methods of therapy for Alzheimer's disease using peptides that bind to the neurotrophin receptor (p75?NTR¿) and competitively inhibit the binding of $g(b)-amyloid to the p75?NTR¿.
(FR)Cette invention se rapporte à des procédés qui servent à évaluer le risque qu'un individu développe la maladie d'Alzheimer et qui utilisent à cet effet des mélanocytes dérivés de la crête neurale mis en culture. Cette invention décrit également des procédés de thérapie de la malade d'Alzheimer qui utilisent des peptides qui se fixent au récepteur de neurotrophine (p75?NTR¿) et qui inhibent de façon compétitive la fixation de $g(b)-amyloïde au récepteur p75?NTR¿.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)