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1. WO1997037043 - METHODS FOR TREATING BIPOLAR MOOD DISORDER ASSOCIATED WITH MARKERS ON CHROMOSOME 18Q

Publication Number WO/1997/037043
Publication Date 09.10.1997
International Application No. PCT/US1997/004904
International Filing Date 27.03.1997
Chapter 2 Demand Filed 29.10.1997
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C12Q 1/6883
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/156
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
C12Q 2600/172
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
172Haplotypes
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • FREIMER, Nelson, B. [US]/[US] (UsOnly)
  • LEON, Pedro [CR]/[CR] (UsOnly)
  • REUS, Victor, I. [US]/[US] (UsOnly)
  • SANDKUIJL, Lodewijk, A. [NL]/[NL] (UsOnly)
  • BARONDES, Samuel, H. [US]/[US] (UsOnly)
Inventors
  • FREIMER, Nelson, B.
  • LEON, Pedro
  • REUS, Victor, I.
  • SANDKUIJL, Lodewijk, A.
  • BARONDES, Samuel, H.
Agents
  • NAKAMURA, Jackie, N.
Priority Data
60/014,49829.03.1996US
60/023,43823.08.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR TREATING BIPOLAR MOOD DISORDER ASSOCIATED WITH MARKERS ON CHROMOSOME 18Q
(FR) PROCEDES DE TRAITEMENT DES TROUBLES AFFECTIFS BIPOLAIRES ASSOCIES A DES MARQUEURS SUR LE CHROMOSOME 18q
Abstract
(EN)
The present invention is directed to methods of detecting the presence of a bipolar mood disorder susceptibility locus in an individual, comprising analyzing a sample of DNA for the presence of a DNA polymorphism on the long arm of chromosome 18 between markers D18S469 and D18S554, wherein the DNA polymorphism is associated with a form of bipolar mood disorder. The invention for the first time provides strong evidence of a susceptibility gene for bipolar mood disorder that is located in the 18q22-q23 region of the long arm of chromosome 18. The disclosure describes the use of linkage analysis and genetic markers in the 18q22-q23 region to fine map the region and the use of genetic markers to genetically diagnose (genotype) bipolar mood disorder in individuals, to confirm phenotypic diagnoses of bipolar mood disorder, to determine appropriate treatments for patients with particular genotypic subtypes. Isolated polynucleotides useful for genetic linkage analysis of BP-I and methods for obtaining such isolated polynucleotides are also described.
(FR)
La présente invention se rapporte à des procédés permettant de déceler la présence d'un locus de sensibilité lié à un trouble affectif bipolaire chez un sujet. Ces procédés consistent à analyser un échantillon d'ADN de façon à déceler la présence d'un polymorphisme d'ADN sur le bras long du chromosome 18 entre les marqueurs D18S469 et D18S554, ledit polymorphisme d'ADN étant associé à une forme de trouble affectif bipolaire. Pour la première fois, l'invention apporte la preuve qu'un gène de susceptibilité associé à un trouble affectif bipolaire est situé dans la région 18q22-q23 du bras long du chromosome 18. L'invention décrit l'utilisation d'une analyse de liaison et de marqueurs génétiques dans la région 18q22-q23 pour cartographier cette région ainsi que l'utilisation de marqueurs génétiques pour effectuer un diagnostic génétique (génotype) des troubles affectifs bipolaires chez des sujets, dans le but de confirmer les diagnostics phénotypiques de trouble affectif bipolaire et d'établir des traitements appropriés pour soigner les patients ayant des sous-types génotypiques particuliers. L'invention concerne en outre des polynucléotides isolés utiles à l'analyse de liaison génétique des troubles affectifs bipolaires graves (BP-I) ainsi que des procédés d'obtention de ces polynucléotides isolés.
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