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1. (WO1997037009) CULTURED INNER CELL MASS CELL LINES DERIVED FROM UNGULATE EMBRYOS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/037009    International Application No.:    PCT/US1997/004736
Publication Date: 09.10.1997 International Filing Date: 24.03.1997
Chapter 2 Demand Filed:    24.10.1997    
IPC:
C12N 15/09 (2006.01), A01K 67/027 (2006.01), C12N 15/877 (2010.01), C12N 5/073 (2010.01), C12N 5/0735 (2010.01), C12N 5/10 (2006.01)
Applicants: UNIVERSITY OF MASSACHUSETTS, A PUBLIC INSTITUTION OF HIGHER EDUCATION OF THE COMMONWEALTH OF MASSACHUSETTS, represented by ITS AMHERST CAMPUS [US/US]; Office of Vice Chancellor for Research at Amherst, Amherst, MA 01002 (US)
Inventors: STICE, Steven, L.; (US).
GOLUEKE, Paul, J.; (US)
Agent: TESKIN, Robin, L.; Burns, Doane, Swecker & Mathis, L.L.P., P.O. Box 1404, Alexandria, VA 22313-1404 (US)
Priority Data:
08/626,054 01.04.1996 US
Title (EN) CULTURED INNER CELL MASS CELL LINES DERIVED FROM UNGULATE EMBRYOS
(FR) LIGNEES DE CELLULES A BOUTON EMBRYONNAIRE CULTIVE, DERIVEES D'EMBRYONS D'ONGULES
Abstract: front page image
(EN)Novel cultured inner cell mass (CICM) cells, and cell lines, derived from ungulates, in particular, pigs and cows, and methods for their preparation are provided. The subject CICMs possess similar morphology and express cell markers identically or substantially similarly to ICMs of undifferentiated developing embryos for prolonged culturing periods. Heterologous DNAs may be introduced into the subject CICM cells and cell lines to produce transgenic cells useful for the production of transgenic embryos, fetuses and/or offspring, e.g., by nuclear transfer procedures.
(FR)L'invention concerne des cellules à bouton embryonnaire cultivé et des lignées de cellules, dérivées d'ongulés - en particulier de truies et de vaches -, et des procédés pour les préparer. Ces boutons embryonnaires cultivés possèdent une morphologie similaire et expriment des marqueurs de cellules de manière identique ou sensiblement similaire aux bouton embryonnaires d'embryons en développement non différenciés, pendant des périodes de culture prolongées. Des ADN hétérologues peuvent être introduits dans lesdites cellules à bouton embryonnaire cultivé et dans lesdites lignées cellulaires pour créer des cellules transgéniques utilisées pour produire des embryons, des foetus ou des descendants transgéniques, par exemple par des techniques de transfert nucléaire.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)