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1. WO1997036923 - PORPHYROMONAS GINGIVALIS ANTIGENS FOR THE DIAGNOSIS AND TREATMENT OF PERIODONTITIS

Publication Number WO/1997/036923
Publication Date 09.10.1997
International Application No. PCT/AU1997/000212
International Filing Date 01.04.1997
Chapter 2 Demand Filed 08.09.1997
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/195 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
C07K 16/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12against material from bacteria
G01N 33/569 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
A61K 2039/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 8/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Applicants
  • THE UNIVERSITY OF MELBOURNE [AU]/[AU] (AllExceptUS)
  • VICTORIAN DAIRY INDUSTRY AUTHORITY [AU]/[AU] (AllExceptUS)
  • REYNOLDS, Eric, Charles [AU]/[AU] (UsOnly)
  • SLAKESKI, Nada [AU]/[AU] (UsOnly)
  • HENDTLASS, Anne [GB]/[AU] (UsOnly)
Inventors
  • REYNOLDS, Eric, Charles
  • SLAKESKI, Nada
  • HENDTLASS, Anne
Agents
  • F.B. RICE & CO.
Priority Data
PN 901229.03.1996AU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PORPHYROMONAS GINGIVALIS ANTIGENS FOR THE DIAGNOSIS AND TREATMENT OF PERIODONTITIS
(FR) ANTIGENES DE PORPHYROMONAS GINGIVALIS POUR LE DIAGNOSTIC ET LE TRAITEMENT DE PERIODONTITES
Abstract
(EN)
The present invention provides a composition for use in raising an immune response directed against $i(Porphyromonas gingivalis). The composition includes a suitable adjuvant and/or acceptable carrier and one substantially purified $i(P. gingivalis) immunogen. The immunogen is selected from the group consisting of Antigen 1, Antigen 2, Antigen 3, Antigen 4 and epitope containing fragments thereof, in which: Antigen 1 is an antigen of $i(P. gingivalis) and has an internal amino acid sequence: DLENKGEATLLVTFGSSYKAPRETYAKIEKTFAAAYPDQR; Antigen 2 is an antigen of $i(P. gingivalis) and has an internal amino acid sequence: DNPDENPLEGDITQTHTEKYVLAED; Antigen 3 is an antigen of $i(P. gingivalis) and has an internal amino acid sequence: DVLLLDVTPLSLGIETMGGVMTYLIDANTTIPKLK; Antigen 4 is an antigen of $i(P. gingivalis) and has an internal amino acid sequence: VYNASISAVGNTSAIDPVVQIIHHN.
(FR)
L'invention concerne une composition destinée à être utilisée pour provoquer une réaction immunitaire contre $i(Porphyromonas gingivalis). La composition comprend un adjuvant approprié et/ou un support acceptable et un immunogène de $i(P. gingivalis) sensiblement purifié. L'immunogène est choisi dans le groupe constitué par l'antigène 1, l'antigène 2, l'antigène 3 et l'antigène 4 et les fragments de ces antigènes contenant l'épitope. L'antigène 1 est un antigène de $i(P. gingivalis) ayant la séquence interne d'aminoacides DLENKGEATLLVTFGSSYKAPRETYAKIEKTFAAAYPDQR; l'antigène 2 est un antigène de $i(P. gingivalis) ayant la séquence interne d'aminoacides DNPDENPLEGDITQTHTEKYVLAED; l'antigène 3 est un antigène de $i(P. gingivalis) ayant la séquence interne d'aminoacides DVLLLDVTPLSLGIETMGGVMTYLIDANTTIPKLK; l'antigène 4 est un antigène de $i(P. gingivalis) ayant la séquence interne d'aminoacides VYNASISAVGNTSAIDPVVQIIHHN.
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