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1. (WO1997036869) N-(2 OXOACETYL OR SULPHONYL)-PYRROLIDINE/PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY

Pub. No.:    WO/1997/036869    International Application No.:    PCT/US1997/004916
Publication Date: Fri Oct 10 01:59:59 CEST 1997 International Filing Date: Tue Mar 25 00:59:59 CET 1997
IPC: C07D 211/60
C07D 401/12
C07D 405/06
C07D 405/12
C07D 405/14
C07D 409/12
Applicants: VERTEX PHARMACEUTICALS INCORPORATED
Inventors: ARMISTEAD, David, M.
SAUNDERS, Jeffrey, O.
Title: N-(2 OXOACETYL OR SULPHONYL)-PYRROLIDINE/PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY
Abstract:
The present invention relates to compounds of formula (I) and (II) that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.